白细胞介素15的研究进展

Research Progresses of Interleukin 15

细胞因子在调节免疫反应中发挥着重要作用,白细胞介素(IL)2常作为免疫佐剂来增强免疫反应。IL-15是一种新近发现的细胞因子,具有与IL-2类似的作用,如激活T细胞、B细胞和自然杀伤细胞,并可介导这些细胞的增殖和存活。IL-15具备IL-2所不具备的优势,如IL-15能激活、维持和扩增CD8+记忆性T细胞,不激活调节性T淋巴细胞(Tregs),并解除Tregs对T细胞的抑制作用,而Tregs对免疫的各个方面都有负调节作用,显示了IL-15在免疫调节中的优势。

Cytokines play important roles in regulating immune responses,and interleukin（IL）2 has been usually used as a potent adjuvant to enhance the immune responses.IL-15 which is discovered recently shares several similar functions with IL-2,including stimulating T-cells/B-cells/NK-cells proliferation.However,IL-15 has some important immunological functions different from IL-2.For example,IL-15 promotes the proliferation and survival of CD8＋ memory T cells rather than apoptosis.IL-15 could impair the functions of regulatory T cells（Tregs）and abolish the inhibition of Tregs to T cells,while Tregs have negative regulation on various immune processes,which suggests IL-15 advantages in immune regulation.