帕金森病非运动症状研究进展

Research Progress of Non-motor Symptoms of Parkinson Disease

目前对帕金森病(PD)的研究多集中在运动症状,对非运动症状的诊断及治疗尚处于较低水平。非运动症状种类繁多,包括睡眠障碍、神经精神症状、自主神经系统症状、消化道症状、感觉障碍等。这些症状可与PD的运动症状并行,也可先于或者晚于运动症状;可随运动症状波动,也可与之无关。今后的PD研究应集中在阐明非运动症状的病理生理机制和探索治疗策略上。

At present,studies of Parkinson disease are mostly focused on motor symptoms,while the diagnosis and treatment of non-motor symptoms is still at a relatively low level.The various non-motor symptoms include sleep disorder,neuropsychiatric symptoms,autonomic nervous system symptoms,gastrointestinal symptoms,and sensory disturbance etc..These symptoms may occur before,during or after the motor symptoms,which may fluctuate together with or be irrelevant to the motor symptoms.Future PD studies should be focused on the pathophysiological mechanisms of non-motor symptoms and exploration of the therapies.