艰难梭菌相关性肠炎的治疗进展

Advances in the Treatment of Clostridium Difficile-associated Colitis

随着抗生素的大量使用导致艰难梭菌相关性肠炎(CDAC)发病率逐渐升高,艰难梭菌(Cd)为其主要致病菌。Cd是一种存在于人类结肠腔内的芽孢状革兰阳性厌氧杆菌,通过粪-口途径传播。CDAC的临床症状轻重不一,可从轻度腹泻到致死性假膜性肠炎和中毒性巨结肠。目前,对Cd在腹泻和结肠炎中的致病作用已有许多研究成果,且建立了一系列相应的治疗方法,为提高CDAC的临床治疗水平,现对其治疗进展予以综述。

With the wide use of antibiotics the incidence of clostridium difficile associated diarrhea（CDAC）has increased dramatically.Clostridium difficile is the main pathogenic bacteria.CDAC has a wide range of clinical features from mild diarrhea to life-threatening pseudomembrannous colitis and toxic megacolon.So far considerable advances have been made in understanding of the pathophysiology of diarrhea and colitis caused by clostridium difficile infection,and a wide variety of treatments are now available.Here is to make a review on progress of the treatment to improve the clinical practice.