伐昔洛韦联合恩再适预防带状疱疹后神经痛的临床观察

Clinical Effect of Valacidovir Combined with Analgecine in the Treatment of Postherpetic Neuralgia

目的观察伐昔洛韦联合牛痘疫苗致炎兔皮提取物注射液预防带状疱疹后神经痛(PHN)的临床疗效及安全性。方法将来解放军三〇三医院皮肤科就诊的80例带状疱疹患者简单随机化分为伐昔洛韦联合恩再适组(A组)和伐昔洛韦组(B组),每组各40例。两组患者均给予伐昔洛韦口服,每次0.3 g,每日2次;A组患者同时静脉注射恩再适7.2U/d,连续5 d。观察两组患者的疼痛减轻时间、消失时间、PHN发生比率。结果 A组疼痛减轻时间为(6.8±4.2)d,疼痛消失时间为(16.5±5.4)d,均较B组(12.2±5.8)d和(26.1±8.1)d明显缩短,差异有统计学意义(P<0.05)。A组PHN发生率为7.5%,B组的发生率为30%,A组明显低于B组,比较差异有统计学意义(P<0.05)。结论伐昔洛韦联合恩再适可缩短PHN疼痛时间,降低PHN的再发生率。

Objective To investigate the effect and safety of valacidovir combined with analgecine in the treatment of postherpetic neuralgia.Methods 80 cases of postherpetic neuralgia from NO.303 Hospital of People′s Liberation Army were randomly divided into valacidovir combined with analgecine group（A） and valacidovir group（B）,40 cases in each group.The patients in two groups were both treated with valaciclovir 0.3 g each time,2 times a day.Analgecine were additionally used in analgecine group with the dosage of 7.2 U/d for 5 days.The pain reliefg time,pain disappearance time and the rate of postherpetic neuralgia of the two groups were observed.Results Group A pain relief time was（6.8±4.2） d and pain disappearance time was（16.5±5.4） d,obviously lower than that of group B（12.2±5.8） d and（26.1±8.1） d（P0.05）.Group A（7.5%） was obvious lower than group B（30%） in the incidence of postherpetic neuralgia（P0.05）.Conclusion Valacidovir combined with analgecine in the treatment of postherpetic neuralgia can shorten pain relief tim and incidence of postherpetic neuralgia.