唾液溶菌酶与β_2微球蛋白在复发性阿弗他溃疡中表达的研究

Study on Expression of Salivary Lysozyme and β_2-Micro Globulin in Recurrent Aphthous Ulcer

目的探讨唾液溶菌酶(Lys)、β2微球蛋白(β2-MG)的表达与复发性阿弗他溃疡(RAU)的发病、治疗及预后的相关性。方法采用酶联免疫吸附定量分析法(ELISA)测定40例口腔RAU患者、40例健康体检者唾液中Lys、β2-MG的表达,并进行比较分析。结果 RAU患者唾液中β2-MG含量较健康组显著升高,Lys含量较健康组明显下降,差异均有统计学意义(P<0.05)。结论联合检测Lys及β2-MG在口腔唾液中的含量对RAU的辅助诊断及治疗具有一定的临床应用价值。

Objective To study the correlation between the expression of salivary lysozyme （Lys）, β2-micro globulin （I32-MG） and onset, treatment and prognosis of patients with recurrent aphthous ulcer（ RAU ）. Methods Lys,β2-MG were detected by ELISA method in 40 cases of RAU and 40 cases of healthy subjects, and comparative analysis was don. Results In saliva of patients with RAU β2-MG content was significantly higher than normal control group, while the oral salivary lysozyme content was markedly lower than the normal control group, and the differences were statistically significant （ P 〈 0.05 ）. Conclusion The combined detection of Lys and 132-MG content in saliva has a clinical application value for RAU auxiliary diagnosis and treatment.