恶性疟原虫AMA-1基因多态性研究进展

Advances on research of AMA-1 gene polymorphisms in Plasmodium falciparum

疟原虫裂殖子顶端膜抗原1(AMA-1)在裂殖子晚期破裂前大量合成抗原物质,在裂殖子黏附、入侵红细胞过程中起到重要作用。近期的研究主要通过对其进行分子生物学及免疫学进行的研究,表明AMA-1可作为疟原虫的重要疫苗候选抗原之一。本文介绍恶性疟原虫AMA-1的分子结构、基因多态性的研究进展,着重分析一些有重要功能的区域片段,基因家族的分类以及造成多态性的原因,为进一步对AMA-1基因多态性研究提供参考。

The apical membrane antigen-1 （AMA-1） is highly expressed in the late schizont stage of the Plasmodium and plays an important role in the merozoite adhesion and invasion of erythrocytes. Recent researches for Plasmodium were carried on the moleeular biology and immunology. These researches show that AMA-1 is a leading malaria vaccine candidate an- tigen. This article gave a detailed introduction about molecular structure and polymorphism of the Plasmodium falciloarum AMA-1 genes and emphasisly analysed some important domains of AMA-1 gene, groups of gene families and the reason of pol- ymorphism to provide the reference for the further study of polymorphism of AMA-1 gene.