肺炎衣原体感染与阿尔茨海默病的关系

Association between Chlamydia pneumonia infection and Alzheimer's disease

阿尔茨海默病(AD)是老年痴呆最常见病因,习惯上分为早发家族性AD(FAD)和迟发性AD(LOAD)。近年来炎症作为LOAD发病因素备受关注,多种研究表明肺炎衣原体(Cpn)感染与LOAD相关。本文介绍了Cpn感染参与LOAD的组织病理学依据、动物模型研究及临床干预实验研究,并探讨Cpn感染导致LOAD可能的发病机制。

Alzheimer＇s disease （AD） is the most common cause of dementia in the elderly, whereby it is customary to distinguish between early familial FAD and late-onset AD （LOAD）. The importance of inflammation in the pathogenesis of LOAD is increasingly being recognized and many studies show that Chlamydia pneumonia （Cpn） has been implicated in LOAD pathogenesis. This review focuses specifically on infection with Cpn in LOAD including the histopathological basis, animal model research and antibiotic treatment studies, and how the infection may function as a ＂trigger or initiator＂ in the pathogene- sis of LOAD.