高踝肱指数与糖尿病患者微血管并发症的相关性研究

Correlation study between high ankle brachial index and microvascular complications in patients with diabetes

目的探讨高踝肱指数（ABI）与糖尿病患者微血管并发症发生的相关性。方法选择2009年3月至2012年3月就诊的2型糖尿病患者共1360例，均行ABI测定，按ABI水平分为ABI〈0．7组、AB10．7—0．9组、0．9〈ABI≤1．3组以及ABI〉1.3组，对ABI与糖尿病患者微血管并发症发生的关系进行单因素分析和Logistic回归分析。结果0．9〈ABI≤1．3组患者1260例，ABI〈0．7组患者20例，AB10．7—0．9组患者60例，ABI〉1．3组患者20例。Logistic回归分析显示与ABI高水平相关的因素是吸烟和收缩压（P〈0．05）。而ABI高水平与微血管并发症糖尿病肾脏病变、糖尿病周围神经病变和糖尿病视网膜病变无明显相关性。结论无糖尿病大血管病变的2型糖尿病患者，ABI高水平并没有增加动脉粥样硬化的危险，且不增加微血管并发症发生率。

Objective To explore the correlation between high ankle brachial index （ABI） and microvascular complications in patients with diabetes. Methods A total of 1360 patients with type 2 diabetes mellitus were selected from March 2009 to March 2012. ABI test was performed in all the patients. The patients were divided into ABI 〈 0.7 group, ABI 0.7 - 0.9 group, 0.9 〈 ABI ~ 1.3 group and ABI 〉 1.3 group according to the ABI level. The correlation between ABI and microvascular complications in patients of type 2 diabetes mellitus was analyzed by single factor analysis and Logistic regression analysis. Results A total of 1260 patients were in 0.9 〈 ABI ~〈 1.3 group, 20 patients in ABI 〈 0.7 group,60 patients in ABI 0.7 -0.9 group,and 20 patients in ABI 〉 1.3 group. Logistic regression analysis showed that related factors of the high ABI level were smoking and systolic blood pressure （P 〈 0.05 ）. The high ABI level showed no correlation with microvascular complications such as diabetic nephropathy,diabetic perineuropathy and diabetic retinopathy. Conclusion In patients with type 2 diabetes mellitus and without diabetic macroangiopathy,the high ABI level does not increase the risk of atherosclerosis and the incidence of microvascular complications.