食管胃结合部癌根治术后早期复发相关因素分析

Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction after curative resection

目的:探讨食管胃结合部癌病人根治术后早期复发的相关临床病理因素。方法 :采用回顾性研究的方法,收集我院1995年12月至2007年12月收治的食管胃结合部癌根治术后复发的147例病人临床资料。通过卡方检验和Logistic多因素回归分析研究影响术后肿瘤早期复发的危险因素。结果:食管胃结合部癌根治术后平均复发时间为16.3±1.2个月,1年内复发率为76.6%。单因素分析结果显示,食管胃结合部癌根治术后早期复发与组织分化类型为低分化/未分化、阳性淋巴结转移数目、脉管浸润相关(P<0.05)。Logistic多因素回归显示,低分化/未分化、脉管癌栓是食管胃结合部癌根治术后早期复发的独立危险因素(P<0.05)。结论:组织分化类型和脉管浸润是预测食管胃结合部癌根治后早期复发的重要因素。

Objective To investigate the clinicopathological factors associated with early recurrence of adenocarcinoma of esophagogastric junction after curative resection. Methods We reviewed clinical data of patients with adenocarcinoma of esophagogastric junction who underwent R0 resection from Dec 1995 to Dec 2007. Risk factors were retrospectively analyzed by X2 test and Logistic multiple regression. Results The mean time to tumor recurrence is （16.3±1.2） months after R0 resection. The calculated 1-year-recurrence is 76.6%. Univariate analysis showed that the histological grade, number of positive lymph nodes and vascular invasion were related with the tumor recurrence time （P〈0.05）. Multi- variate Logistic multiple regression analysis showed that histologic grade and vascular invasion were independently related with early tumor recurrence （P 〈0.05）. Conclusions Histological grade and vascular invasion are significant and independent factors for predicting the tumor recurrence of adenocarcinoma of esophagogastric junction after R0 resection.