期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

去泛素化酶锌指蛋白A20调控NF-κB信号通路的研究进展 被引量：5

下载PDF
导出
摘要 NF-κB是众多生理过程的关键调节位点。泛素化和去泛素化在NF-κB信号通路中起着重要的调节作用。锌指蛋白A20(又称TNFAIP3)为炎性反应的内源性调控蛋白和组织细胞保护性蛋白,它通过可逆的去泛素化以及泛素化功能下调活化的NF-κB通路,从而维持免疫稳态,控制炎性反应。
作者 艾罗燕 范竹萍
机构地区 上海市消化疾病研究所 上海交通大学医学院附属仁济医院健康保健中心
出处 《国际消化病杂志》 CAS 2013年第1期43-46,共4页 International Journal of Digestive Diseases
基金 中国肝炎防治基金会王宝恩肝纤维化研究基金(20110002)
关键词 A20 NF—κB 泛素化 去泛素化酶 免疫
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献2

二级参考文献164

  • 1Compagno M, Lim WK, Grunn A, et al. Mutations ofmultiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 2009; 459:717-721.
  • 2Montesinos-Rongen M, Schmitz R, Brunn A, et al. Mutations of CARDll but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma. Acta Neulvpatho12010; 120:529-535.
  • 3Lamason RL, McCully RR, Lew SM, Pomerantz JL. Oncogenic CARD 11 Mutations Induce Hyperactive Signaling by Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain. Biochemistry 2010; 49:8240-8250.
  • 4Hailfinger S, Lenz G, Ngo V, et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. ProcNatlAcadSci USA 2009; 106:19946-19951.
  • 5Ferch U, Kloo B, Gewies A, et al. Inhibition of MALT1 protease activity is selectively toxic for activated B celllike diffuse large B cell lymphoma cells. J Exp Med 2009; 206:2313-2320.
  • 6Davis RE, Brown KD, Siebenlist U, Staudt LM. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med2001; 194:1861-1874.
  • 7Lam LT, Davis RE, Pierce J, et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profi- ling. Clin Cancer Res 2005; 11:28-40.
  • 8Grabiner BC, Blonska M, Lin PC, et al. CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev 2007; 21:984-996.
  • 9Lefkowitz RJ. Historical review: a brief history and personal retrospective of seven-transmembrane receptors. Trends Pharmaeol Sci 2004; 25:413-422.
  • 10Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 2003; 3:582-591.

共引文献36

同被引文献55

  • 1闰玮,刘家云,苏明权,李晓瑾,郝晓柯.A20在前列腺癌细胞中的表达[J].细胞与分子免疫学杂志,2007,23(3):232-233. 被引量：5
  • 2Coornaert B, Carpentier I, Beyaert R. A20:central gatekeeper in inflammation and immunity [ J ]. J Biol Chem, 2009, 284 ( 13 ) : 8217-8221.
  • 3Chng HW, Camplejohn RS, Stone MG, et al. A new role for the autiapoptotic gene A20 in angiogenesis [ J ]. Exp Cell Res, 2006, 312( 15 ) : 2897-2907.
  • 4Moore PB, Steitz TA. The involvement of RNA in ribosome function [ J ]. Nature, 2002, 418 ( 6894 ) : 229-235.
  • 5Evans PC. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity [ J 1. Biochem J, 2004, 378 ( 3 ) : 727-734.
  • 6Stahel PF, Flied MA. Targeted modulation of the neuroinflammatory response after spinal cord injury the ongoing quest for the "holy grail" [ J ]. Am J Pathol, 2010, 177 ( 6 ) : 2685-2687.
  • 7Lee TH, Shank J, Cusson N, et al. The kinase activity of Ripl is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Ripl by Traf2 [ J ]. J Biol Chem, 2004, 279 ( 32 ) : 33185-33191.
  • 8Kanayama A, Seth RB, Sun LJ, et al. TAB2 and TAB3 activate the NF- kappa B pathway through binding to po]yubiquitin chains [ J ]. Mol Cel, 2004, 15(4) : 535-548.
  • 9Vendrell JA, Ghayad S, Ben-Larbi S, et al. A20 / TNFAIP3 ,a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells [ J ]. Oneogene, 2007, 26 ( 32 ) : 4656-4667.
  • 10Vaziri SA, AI-Hazzouri A, Grabowski DR, et al. Sorafenib treatment of clear-cell renal cell carcinoma ( CCRCC ) and colorectal carcinoma ( CRC ) cells:differential effects on gene expression and cell death pathways [ J ]. J Clin Oncol, 2007, 25 ( 18 ) : 15612.

引证文献5

二级引证文献4

国际消化病杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部