强的松联合吗替麦考酚酯治疗血管炎型IgA肾病的疗效及对血清中转化生长因子β_1的影响

Efficacy observation and TGF-β_1 detection in patients with vasculitis type IgA nephropathy treated by mycophenolate mofetil and prednisone.

目的探讨强的松联合吗替麦考酚酯治疗血管炎型IgA肾病的疗效及对血清中转化生长因子β1(TGF-β1)的影响。方法收集我院确诊的88例血管炎型IgA肾病,依患者的入院顺序分为观察组与对照组,观察组44例,在常规治疗基本上加用强的松联合吗替麦考酚酯治疗;对照组44例,在常规治疗基础上加用强的松治疗,观察治疗的效果及治疗前、治疗后血清中TGF-β1的变化。结果观察组的疗效明显优于对照组(93.18%vs77.27%),两组患者治疗后血清中TGF-β1的含量均下降,但是观察组患者的下降值明显高于对照组[(65.08±8.63)ng/Lvs(40.89±8.32)ng/L]。结论强的松联合吗替麦考酚酯治疗血管炎型IgA肾病患者临床疗效明显,且能显著降低血清中TGF-β1的含量,值得临床推广应用。

Objective To observe the curative effect, TGF-β1 change in patients with vasculitis type IgA ne-phropathy treated by mycophenolate mofetil and prednisone. Methods Eighty-eight patients with vasculitis type IgA nephropathy were divided into two groups. The control group （44 cases） were treated by routine treatment and predni-sone, the observation group （44 cases） were added mycophenolate mofetil and prednisone. We observated the efficacy and the change of TGF-β1l in two groups. Results The total effective rate was obviously higher in the observation group than that in the control group （93.18% vs 77.27%）. The change value of TGF-β1 were obviously higher in the observation group after treatment [（65.08±8.63） ng/L vs （40.89±8.32） ng/L]. Conclusion Mycophenolate mofetil and prednisone can improve the curative effect, regulate the expression of TGF-β1 in patients with vasculitis type IgA nephropathy.