伴与不伴有精神病性症状的抑郁症患者临床特征比较

Comparison on the clinical features of the depressive patients with or without psychotic symptoms.

目的探讨伴与不伴有精神病性症状的抑郁症患者在临床特征和治疗方面的差异。方法采用回顾性研究的方法,使用自编调查问卷,对符合研究方案的116例患者的人口学资料、临床表现及住院治疗情况等进行统计分析,其中36例伴精神病性症状者为研究组,80例不伴精神病性症状者为对照组。结果 (1)两组患者在现患年龄、病前性格特征和病程方面差异有统计学意义(P<0.05),研究组平均年龄低于对照组,且多为内向性格,总病程较短;(2)注意减退和躯体症状两个临床特征在两组间存在统计学意义(P=0.05和0.002),研究组较对照组而言存在注意减退者居多而躯体症状相对较少;研究组对疾病的认识程度不如对照组;(3)治疗方面,研究组需要合并用药才能达到预期疗效。结论伴和不伴有精神病性症状的抑郁症患者在临床特征和治疗方面均有一定差异,临床工作中我们应区别对待。

Objective To investigate the difference of clinical features between depressive patients with psy-chotic symptoms and those without. Methods Applying self-designed questionnaire, the demographic data, clinical manifestation and treatment status of 116 patients were retrospectively analyzed. Thirty-six of the patients with psy-chotic symptoms were enrolled as the study group, and 80 without psychotic symptoms were enrolled as the control group. Results （1） There were statistically significant difference between the two groups in age, personalities and dis-ease course （P〈0.05）. Patients in the study group was younger, introversive, with shorter disease course. （2） Hypopro-sexia and somatic symptoms showed statistically significant different between the two groups （P=0.05 and 0.002）. Compared with the control group, the study group had higher incidence of hypoprosexia and fewer somatic symptoms. The recognition of disease in the study group was no better than that in the Control group. （3） In the aspect of treat- ment, drug combination was needed in the study group. Conclusion There are certain differences in the clinical fea-tures and treatment between depressive patients with psychotic symptoms and those without psychotic symptoms, which should be treated discriminately.