门脉高压性胃病相关危险因素分析

Analysis on the risk factors of portal hypertensive gastropathy.

目的探讨门脉高压性胃病(PHG)的相关危险因素。方法选取肝硬化并发PHG患者103例为PHG组,未并发PHG患者132例为对照组。分别从年龄、肝硬化病程、幽门螺杆菌(Hp)、凝血酶原时间(PT)、血清白蛋白(ALB)、门静脉主干内径(PVD)、脾门静脉内径(SVD)、脾长径(SPL)、脾厚度(SPT)等相关指标进行比较分析。结果 PHG组在年龄、肝硬化病程、Hp、PT、ALB、PVD、SVD、SPT等方面与对照组比较差异均有统计学意义(P<0.01或P<0.05)。经Logistic逐步分析发现,肝硬化病程、PT、ALB、PVD与PHG关系密切。结论肝硬化病程、PT、ALB、PVD是PHG危险因素,临床上应根据其变化情况及早进行干预,对提高肝硬化患者生活质量将具有重要意义。

Objective To investigate the risk factors of portal hypertensive gastropathy （PHG）. Methods One hundred and three liver cirrhosis patients with PHG were enrolled as the PHG group, and 132 liver cirrhosis patients without PHG were enrolled as the control group. The two groups were compared in age, course of cirrhosis, Helico-bacter pylori （lip）, prothrombin time （PT）, serum albumin （ALB）, diameter of main portal vein （PVD）, diameter of spleen portal vein （SVD）, length of spleen （SPL）, thickness of spleen （SPT）. Results There were statistically signifi- cant differences between the PHG group and the control group in age, course of cirrhosis, Hp, PT, ALB, PVD, SVD, SPT（P〈0.01 or P〈0.05）. Multivariate regression analysis revealed significant correlation between course of cirrhosis, PT, ALB, PVD and PHG. Conclusion Course of cirrhosis, PT,.ALB, PVD are the risk factors of portal hypertensive gas- tropathy. Clinically, early intervention should be performed in time according to changes of these factors, which are of great significance to the improving of the life quality of liver cirrhosis patients.