胎盘生长因子在膀胱移行细胞癌中的表达及临床意义

The expression and clinical significance of PLGF in bladder transitional cell carcinoma

目的探讨胎盘生长因子在膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法采用免疫组织化学法,检测30例BTCC及10例正常膀胱粘膜组织胎盘生长因子的表达。结果胎盘生长因子(PLGF)在BTCC组织中的表达明显高于正常膀胱粘膜组织(56.7%/10%,P<0.05);胎盘生长因子在膀胱移行细胞癌G2、G3级组织中的表达明显高于G1级;胎盘生长因子在膀胱移行细胞癌T2～T4期中的表达明显高于Tis～T1期。PLGF在BTCC中男女两组间表达的阳性率分别为:52.6%、63.6%,无显著差异。结论随着膀胱移行细胞癌病理分级的升高,癌组织中PLGF的表达也随之增加。PLGF在浸润性膀胱癌中的表达明显高于非浸润性膀胱癌,并且无性别差异。

Objective To investigate the exepression and clinical significance of Placenta growth factor （PLGF） in bladder transitional cell carcinoma （BTCC）. Methods PLGF Expression in 30 cases of BTCC and 10 cases of normal epithelium was detected by immunohistochemical assay. Results PLGF ex- pression in BTCC was higher than that in the normal epithelium. Moreover, PLGF expression in G2 and G3 tissues of BTCC was higher than that in G1 tissue. Compared with the stage of Tis - T1, the higher PLGF expression rate was shown in the stage of T2 - T4 of BTCC. Furthermore, there was no significant difference of PLGF expression in BTCC between men and women. Conlusion PLGF expression gradually increases with the development of BTCC pathological grading. PLGF expression in invasive BTCC is higher than that in non -invasive BTCC with no sigficant difference between men and women.