摘要
目的研究胃癌组织中微血管密度(MVD)和血红素氧合酶-1(HO-1)的表达与胃癌血管生成及侵袭转移的关系。方法联合应用组织芯片技术及免疫组织化学(S-P)法对61例人胃癌组织中MVD和HO-1的表达进行检测,分析两者的表达水平与临床病理特征的相互关系。结果 MVD和HO-1在胃癌中的阳性表达平均值高于正常胃黏膜组织(P<0.05);且与肿瘤分期、分化程度、浸润深度的相关性均有统计学意义(P<0.05)。结论胃癌组织中MVD和HO-1呈高表达状态,可能对肿瘤细胞的血管生成和转移提供有利条件。
Objective To study the microvessel density（MVD）and the expression of heme oxygenase-1（HO-1）in gastric carcinoma tissues and its relationship with angiogenesis,invasion and metastasis of gastric carcinoma.Methods The tissue microarray and immunohistochemical method were adopted to detect MVD of HO-1 expression in 61 cases of human gastric cancer patients and the correlation between the expression level and clinical pathological features was analyzed.Results The MVD and the positive expression level of HO-1 in gastric cancer were higher than those in normal gastric mucosa（P0.05）,and there had significant difference in tumor stage,histological differentiation,depth of invasion between the two groups（P0.05）.Conclusion MVD and HO-1 expression are high in gastric carcinoma,which may provide favorable conditions for angiogenesis and metastasis of tumor cells.
出处
《湖北科技学院学报（医学版）》
2012年第6期477-479,共3页
Journal of Hubei University of Science and Technology(Medical Sciences)
基金
咸宁学院2011年度校级科研项目(KY11078)
