银杏叶提取物联合恩替卡韦对慢性乙肝致肝纤维化的干预研究

Study of the Intervention Effect of Combination Ginkgo Biloba Extract with Entecavir on Chronic Hepatitis B Induced Liver Fibrosis

目的:探讨银杏叶提取物(EGb761)联合恩替卡韦对慢性乙型肝炎患者肝纤维化指标的影响。方法:将45例慢性乙型肝炎患者分为治疗组22例及对照组23例,治疗组应用EGb761及恩替卡韦治疗,对照组仅予恩替卡韦治疗,连续治疗2个月。治疗前后分别检测肝功能、Ⅲ型前胶原(PCⅢ)、Ⅳ型前胶原(PCⅣ)、透明质酸(HA)、层黏连蛋白(LN)水平。结果:治疗后治疗组肝纤雏化指标较对照组明显改善(P均<0.001)。结论:银杏叶提取物EGb761恩替卡韦联合应用对慢性乙肝有明显的抗肝纤维化作用。

Objective： To investigate effect of combination Ginkgo biloba extract with entecavir on chronic hepatitis B induced liver fibrosis.Methods： 45 patients with chronic hepatitis B patients were divided into two groups,namely normal control group and test group.In test group,EGb761 and entecavir were administered in 22 cases of patients for two months,while in control group,23 cases of patients were given entecavir only.Liver function,procollagen（PCm） type III,procollagen（PC1V） type1v,hyaluronic acid（HA）,laminin（LN） were detected.Results： Liver fibrosis improved significantly compared with control group（P 0.001）.Conclusion： Combination of Ginkgo biloba extract EGb761 with entecavir has significant anti liver fibrosis effect on chronic hepatitis B.