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PAAm/PEG/PVP半互穿网络水凝胶的制备、表征及茶碱释放研究 被引量:1

Synthesis,Characterization and Theophylline Release Profiles of PAAm/PEG/PVP Hydrogels with Semi-Interpenetrating Networks
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摘要 以N,N-亚甲基双丙烯酰胺(N,N-MBA)为交联剂、过硫酸钾(KPS)为引发剂,通过丙烯酰胺(AAm)、聚乙二醇(PEG)和聚乙烯吡咯烷酮(PVP)发生共聚反应制备具有半互穿网络结构的水凝胶PAAm/PEG/PVP。采用红外光谱(FTIR)、热重分析(TG)对水凝胶的结构和热学性质进行了分析,研究了中性条件下水凝胶的溶胀性能,并进一步研究了其负载茶碱在不同缓冲溶液中的释放行为。 The PAAm/PEG/PVP hydrogels with semi-interpenetrating networks(semi-IPN) composed of co-polymer networks of aerylamide (AAm), polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) was synthesized by a co-polymerization reaetion in the presence of N, N-methylene bisaerylamide(N, N-MBA) as crosslinker and potassium persulfate (KPS) as initiator. The PAAm/PEG/PVP hydrogels was characterized by using Fourier transform infrared spectroscope (FTIR),thermogravimetric analysis (TG). The swelling behav- ior of hydrogels under the neutral conditions was investigated. The in vitro release profiles of the model drug theophylline from the hydrogels was also examined.
出处 《化学与生物工程》 CAS 2013年第2期47-49,60,共4页 Chemistry & Bioengineering
基金 陕西省教育厅专项研究计划资助项目(11JK0587) 延安大学科研启动基金资助项目(YD2009-07)
关键词 半互穿网络水凝胶 溶胀率 药物释放 hydrogel with semi-interpenetrating networks swelling rate drug release
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