复方苦参注射液联合SP方案治疗晚期胃癌的临床观察

Clinical Observation of Compound Matrine Injection Combined with SP Regimen in Advanced Gastric Cancer

目的探讨复方苦参注射液联合SP方案治疗晚期胃癌的临床效果。方法选取2010年6月至2011年11月在我院治疗的晚期胃癌患者76例。随机分为治疗组和对照组,两组患者分别采用复方苦参注射液联合SP方案治疗与SP方案治疗,比较患者临床治疗效果。结果治疗组患者治疗有效率为57.5%,对照组为52.8%,两组患者治疗效果并无明显差异。两组患者除恶心呕吐症状发生率无明显差异外,其他各项指标发生率治疗组均低于对照组。结论复方苦参注射液联合SP方案治疗晚期胃癌可明显降低患者治疗过程中白细胞异常率、血红蛋白异常率、肝功异常率、腹泻便秘发生率及神经毒性发生率,提高晚期胃癌患者生存质量。

Objective To investigate the clinical effect of compound matrine injection combined with SP in the treatment of advanced gastric cancer effect. Methods 76 cases with advanced gastric cancer were collected in our hospital from June 2010 to November 2011 and randomly divided into experimental group and control group. Patients in the two groups were treated with compound matrine injection combined with SP regimen and SP regimen respectively; clinical effect of the two groups was compared. Results The effective rate of experimental group and control group was 57.5% and 52. 8% respectively. Therapeutic effect of the two groups of patients did not differ significantly. Except that there was no significant difference in terms of nausea and vomiting symptoms, occurrence rate of other indexes of the treatment group were lower than those of control group. Conclusion The treatment of advanced gastric cancer with compound matrine injection combined with SP program can significantly reduce the abnormal rate of white blood cells, the abnormal rate of hemoglobin, the abnormal rate of liver function, the incidence of diarrhea and constipation and the incidence of neurotoxicity, so as to improve the life quality of patients with advanced gastric cancer.