胃泌素对大肠癌的促生长作用及抗胃泌素治疗进展

The Growth-promoting Effect of Gastrin on Colorectal Cancer and the Development of Anti-gastrin Treatment

胃泌素(Gas)广泛存在于胃肠道和胰腺组织内,在调控生理功能及某些疾病的发病机制中都有重要作用。近来研究表明,胃泌素能够促进肿瘤尤其是胃癌、大肠癌等消化系肿瘤的发生、发展。胃泌素促进细胞增殖、抑制凋亡的作用,揭示了其临床用于大肠癌内分泌治疗的美好前景。

Gastrin exists widely in gastrointestinal tract and pancreatic tissues, and plays an important role in the adjustment of physiological functions and pathogenic mechanism of some diseases. Recent studies show that gastrin might lead to the development of tumors, especially digestive tumors such as gastric cancer and colorectal cancer. It is promising to apply gastrin clinically to endocrine therapy for gastrin can speed up cell proliferation and inhibit apoptosis.