检测冠心病患者炎性标志物对评估病情的临床意义(英文)

Significance of detection of inflammatory markers for assessing patient′s condition in patients with coronary heart disease

目的:探讨检测血清超敏C反应蛋白(hsCRP)、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)对评估冠心病(CHD)患者病情的临床意义。方法:检测78例接受经皮冠状动脉介入术治疗(PCI)治疗的CHD患者入院前及入院3个月后血清hsCRP、TNF-α和IL-8水平。其中包括急性心肌梗死(AMI)17例,不稳定型心绞痛(UAP)36例,稳定型心绞痛(SAP)25例。另47例健康人设为正常对照组。结果:(1)与正常对照组比较,AMI组和UAP组患者血清hsCRP[(1.96±0.60)mg/L比(22.43±9.68)mg/L、(18.27±8.56)mg/L]、TNF-α[(11.26±3.82)ng/L比(60.12±19.37)ng/L、(40.33±15.48)ng/L]和IL-8[(48.26±20.87)ng/L比(120.36±33.32)ng/L、(105.92±34.2)ng/L]水平明显升高(P均<0.01),且Pearson直线相关分析显示hsCRP与TNF-α、IL-8水平呈正相关(r=0.873～0.956,P均<0.01);(2)SAP组PCI前血清hsCRP水平[(6.04±2.38)mg/L]较正常对照组明显升高(P<0.01);(3)与PCI术前比较,CHD患者PCI 3个月后血清hsCRP[(13.89±6.13)mg/L比(2.06±1.42)mg/L]、TNF-α[(38.26±14.27)ng/L比(13.76±4.12)ng/L]和IL-8[(98.96±32.9)ng/L比(50.12±19.85)ng/L]水平明显下降(P均<0.01),较正常对照组无明显差异(P均>0.05)。结论:检测冠心病患者血清hsCRP、TNF-α和IL-8对冠心病的诊疗、预后预测有一定的临床意义。

Objective： To study significance of detection of serum levels of high sensitive C reactive protein （hsCRP）, tumor necrosis factor-α（TNF-α） and interleukin-8 （IL-8） for assessing patient＇s condition in patients with coronary heart disease （CHD）. Methods.. Serum levels of hsCRP, TNF-α and IL-8 were measured in 78 CHD patients under- going percutaneous coronary intervention （PCI） before and three months after PCI. Among CHD patients, there were 17 patients with acute myocardial infarction （AMI）, 36 patients with unstable angina pectoris （UAP） and 25 patients with stable angina pectoris （SAP）. Their levels of above indicators were compared with those of 47 healthy subjects （normal control group）. Results： （1） Compared with normal control group, there were significant increase in serum levels of hsCRP[ （1.96±0.60） mg/L vs. （22.43±9.68） mg/L, （18.27±8.56） mg/L], TNF-α [ （11.26 ±3.82） ng/Lvs. （60.12±19.37） ng/L, （40.33±15.48） ng/L] and IL-8 [（48.26±20.87） ng/L vs. （120.36± 33.32） ng/L, （105.92±34.2） ng/L] in AMI group and UAP group before treatment （P〈0.01 all）, and Pearson linear correlation analysis showed that hsCRP was positively correlated with levels of TNF-α and IL-8 （r=0. 873- 0. 956, P〈0.01 all） ; （2） Serum level of hsCRP in SAP group [（6.04±2.38） mg/L] was significantly higher than that of normal control group （P〈0. 01） ; （3） Compared with before PCI, there were significant decrease in serum levels ofhsCRP [ （13.89±6.13） mg/Lvs. （2.06±1.42） mg/L], TNF-α [（38.26±14.27） ng/L vs. （13.76± 4.12） ng/L] and IL-8 [ （98.96±32.9） ng/L vs. （50.12±19.85） ng/L] in CHD patients three-month after PCI （P〈0.01 all）, and they were no significant difference compared with normal control group （P〉0.05 all）. Conclu- sion： Detections of serum levels of hsCRP, TNF-α and IL-8 in CHD patients are of certain significance for diagno-sis, treatment and prognosis prediction of CHD.