普瑞巴林联合经皮电刺激治疗带状疱疹后遗神经痛的疗效

Curative effectiveness of oral pregabalin combined with transcutaneous electric nerve stimulation in the treatment of abdominal postherpetic neuralgia

目的:观察口服普瑞巴林联合经皮电刺激治疗腹部带状疱疹后遗神经痛(PHN)的临床效果。方法:腹部PHN患者52例,随机分为2组各26例。对照组口服普瑞巴林300mg,每天2次;观察组在此基础上给予患处经皮神经电刺激(TENS)治疗。用视觉模拟疼痛评分(VAS)和睡眠质量评分(QS)评价效果,并观察治疗后的不良反应。结果:治疗1、2、3及4周后,2组VAS和QS评分均显著下降(均P<0.05),观察组降低较对照组更明显(均P<0.05)。2组不良反应比较差异无统计学意义。结论:口服普瑞巴林300mg联合TENS治疗可有效缓解腹部PHN,改善睡眠质量,且无明显不良反应。

Objective.. To observe the effectiveness of oral pregabalin combined with transcutaneous electric nerve stimulation in the treatment of postherpetic neuralgia. Methods：Fifty-two cases of postherpetic neuralgia were randomly divided into control group and observation group. Both groups were given oral pregabalin 300 rag,twice daily for 4 weeks,and observation group was given transcutaneous electric nerve stimulation in the pain spot additionally, Visual analogue scale （VAS） and sleep quality score （QS） were used to assess the effects,and adverse reactions were observed. Results ： After treatment for 1,2,3,4 weeks, VAS and QS scores were significantly decreased in both groups as compared with pretreatment（all P〈0.05）, more significantly in observation group than in control group （all P〈0.05）. The adverse effects between the two groups had no significant difference. Conclusion：Pregabalin plus transcutaneous electric nerve stimulation can effectively relieve postherpetic neuralgia and improve sleep quality,with no obvious adverse effects.