子午流注序贯穴位埋线治疗HBeAg阴性乙肝病毒携带者外周血T细胞亚群变化的临床观察

Changes of T cell subsets of HBV carriers with negative HBeAg treated by midnight-midday ebb flow sequential catguting embedment in acupoint

目的:观察子午流注序贯穴位埋线治疗HBeAg阴性乙肝病毒携带者外周血T细胞亚群的变化。方法:将120例HBeAg阴性乙肝病毒携带者随机分为治疗组60例和对照组60例,治疗组予子午流注序贯穴位埋线治疗,疗程3个月;对照组给予口服胸腺肽肠溶片治疗,疗程3个月。采用流式细胞仪检测T细胞亚群的变化情况。结果:两组相比,血CD4+T细胞、CD8+T细胞百分比及CD4+T/CD8+T较治疗前明显增加,差异均有统计学意义(P<0.05)。结论:子午流注序贯穴位埋线治疗HBeAg阴性乙肝病毒携带者,可以有效改善患者细胞免疫功能状态,提高临床疗效。

Objective： To investigate the changes of T cell subsets of patients with negative HBeAg treated by midnight- midday ebb flow sequential catguting embedment in acupoint. Methods： One hundred-twenty cases of chronic hepatitis B without HBeAg were divided into two groups randomly： the therapeutic group - midnight-midday ebb flow sequential catguting embedment in acupoint （once a week） and the control group -thymopeptides enteric-coated tablets, three monthes as a period of treatment. Results： The percentage of CD4 ^＋ T cells, CD8 ^＋ T in peripheral blood of therapeutic group were significantly increased （ P 〈 0. 05） . Conclusion： Midnight-midday ebb flow sequential catguting embedment in acupoint can improve T lymphocyte subsets imbalances and cellular immune of the chronic hepatitis B without HBeAg.