KLK11在卵巢肿瘤组织中的表达及其临床相关性

The expression of KLK11 in ovarian neoplasm and the correlation between its expression and prognosis

目的探讨KLK11基因在卵巢癌组织中的表达状况。方法应用免疫组织化学检测KLK11在卵巢癌组织、良性卵巢肿瘤组织及正常卵巢组织中的表达状况。结果 KLK11蛋白在正常卵巢上皮细胞中均有表达;KLK11在卵巢癌组织中的表达均低于其在正常卵巢组织和良性卵巢肿瘤组织的表达(P=0.016,P=0.013);KLK11在浆液性卵巢癌组织的表达高于其他类型的卵巢癌组织(P=0.045,P=0.012);早期卵巢癌组织中(Ⅰ/Ⅱ期)KLK11的表达明显高于晚期卵巢癌(Ⅲ/Ⅳ期)(P=0.002,P=0.010);KLK11在卵巢癌组织的表达水平与肿瘤的病理分级无明显关系(P=0.510,P=0.747);KLK11表达与卵巢癌淋巴结转移等预后因素有明显相关性(P=0.027);KLK11阳性与阴性患者的平均生存时间分别为39.3个月和28.9个月(P=0.031)。结论 KLK11在卵巢癌组织中表达下调,且其表达与卵巢癌的临床分期以及淋巴结转移有相关性,提示KLK11的表达失调可能对卵巢癌的诊断及预后有一定价值。

Objective To investigate the expression of KLK11 in ovarian cancer. Methods All these cases were divided into three groups： malignant ovarian cancer group, benign ovarian tumor group and normal ovarian tissue group. The expression of KLK11 protein in three groups was examined by means of immunohistochemistry . The correlation between its expression and tumour clinical stages,histopathology grouping was also studied. Results The expression of KLKI 1 protein increased gradually in three groups; the expression of KLK11 was significantly lower in ovarian cancer than that in benign ovarian tumor and normal ovari- an tissue（P =0. 016,P = 0. 013） ;the expression of KLK11 in serous type was higher than that in other types of ovarian cancer （P =0. 045 ,P =0. 012） ;the expression of KLKll in early stage of ovarian cancer（ Ⅰ / Ⅱ stage） was significantly higher than that in late stage（ Ⅲ/Ⅳ stage） （ P = 0. 002 ,P = 0. 010 ） ; there was no correlation between the expression level of KLK11 and patholog- ical stages of ovarian cancer（ P = 0.510, P = 0. 747）. There was signifieanl correlation between the expression level of KLK11 and clinical stages , histological types of ovarian cancer and metastatic lymph node. Survival between positive and negative group of KLK11 were 39. 3 and 28. 9 months respectively （ P = 0. 031 ）. Conclusion The expression of KLK11 was existed in ovarian cancer, benign ovarian tumor and normal ovarian tissue. The expression of KLK11 was Correlated with the clinicopathological fea- tures of ovarian cancer.