慢性生活压力对血管内皮功能的影响及中药干预研究

Study on Influence of Life Pressure on Vascular Endothelial Function and TCM Interventions

目的:从慢性生活压力因素对血管内皮功能影响的角度,探讨中药调畅情志作用与内皮功能保护之间关系及其可能机制。方法:按入选标准分为慢性生活压力组和正常对照组。以逍遥散为主方,随证加减。检测内皮功能生化指标及超声指标。结果:与正常组比较,慢性生活压力组治疗前的NO、ET、TXB2、6-keto-PG1α均有明显的差异(P<0.05);慢性生活压力组经治疗后6-keto-PG1α明显升高(P<0.05),ET明显降低(P<0.05);TXB2及内皮依赖性舒展功能(EDD)明显改善(P<0.05)。结论:(1)慢性生活压力对血管内皮功能会造成明显的损伤;(2)调畅情志治疗可改善因慢性生活压力造成的内皮损伤。

Objective ： To explore the role of traditional Chinese medicine regulating emotions and the relationship with endothe- lial protection function and its possible mechanism. Methods ： According to inclusion criteria, patients were divided into 2 groups ： chronic pressure group and the normal control group. According to the patients types, traditional Chinese medicines for adjusting emotion such as bupleuri, finger citron, spikenard, paeoniae, turmeric, Fructus Toosendan, were used. The endothelial functions were detected with biochemistry and ultrasound methods. Results：Compared with normal group, there were significant differences （ P 〈 0. 05 ） in NO, ET, TXB2 and 6 - keto - PG1 ct of chronic pressure group before treating; after treatment 6 - keto - PG1 ct in chronic pressure group was significantly higher（ P 〈 0.05 ）, ET decreased significantly （ P 〈 0.05 ） ; TXB2 and endothelial - de- pendent dilation（EDD） in chronic pressure group improved significantly （P 〈 0. 05 ）. After regulating emotion treatment, NO in chronic pressure group was significantly higher（ P 〈 0.05 ）. Conclusion： （ 1 ） Chronic pressure can significantly damage vascular endothelial function. （2） Regulating emotions treatment can improve the result of endothelial injury caused by chronic pressure.