胃萎Ⅰ号颗粒对急性胃黏膜损伤模型大鼠胃黏膜的保护作用研究

Study on Protective Effect of Weiwei No.1 Granule on Gastric Mucosa in Acute Gastric Mucosal Lesion Model Rats

目的:观察胃萎Ⅰ号颗粒对急性胃黏膜损伤大鼠的胃黏膜保护作用。方法:将30只SD大鼠随机分为正常组、模型对照组、胃萎Ⅰ号组和替普瑞酮组,采用60%乙醇灌胃制备急性胃黏膜损伤大鼠模型,观察胃萎Ⅰ号颗粒对大鼠胃黏膜损伤的影响,并测定血清和胃黏膜组织中PGE2、EGF、SS的含量。结果:胃萎Ⅰ号组和替普瑞酮组均能明显改善黏膜损伤状况,并能显著提高血清和胃组织中PGE2、EGF、SS的含量,较模型对照组均有显著性差异(P<0.01);且胃萎Ⅰ号组对EGF、SS含量的提高优于替普瑞酮组(P<0.05)。结论:胃萎Ⅰ号颗粒具有保护胃黏膜的作用,其机理可能与促进EGF、SS、PGE2等胃黏膜保护因子的生长有关。

Objective：To observe the protective effect of Weiwei No. 1 Granule on gastric mucosa in acute gastric mucosal le- sion rats. Methods ：30 SD rats were randomly divided into four groups：normal group, model group, Weiwei No. 1 group and te- prenone group. Acute gastric mucosal lesion in rat model was prepared with 60% ethanol by garage. Effects of gastric mueosa damage and the contents of EGF, SS, and PGE2 in serum and gastric tissues were obsetwed. Results：Compared to the model group, both Weiwei No. 1 treatment group and western medicine treatment group could improve gastric mucosa, and significantly improve the contents of EGF, SS and PGE2 in serum, and gastric tissues, showing significant difference （ P 〈 0. 01 ）. And Weiwei No. 1 group can improve the contents of EGF and SS better than Teprenone group （ P 〈 O. 05 ）. Conclusion ： Weiwei No. 1 Granule can protect gastric mucosa, and its mechanism may be related to the influence on levels of EGF, SS and PGE2.