胺碘酮治疗骨伤科围术期快速性心律失常的疗效观察

Efficacy of Amiodarone for Tachyarrhythmia in Orthopedic Patients During Perioperative Period

目的:观察静脉应用胺碘酮治疗骨伤科围术期快速性心律失常的临床疗效及安全性。方法:收集184例围术期快速性心律失常的骨伤科患者,以随机抽样法分为2组,治疗组(92例)先静脉注射负荷量的胺碘酮,继以静脉滴注维持,对照组(92例)给予注射用酒石酸美托洛尔静脉注射,1日1次,观察2组治疗心律失常的疗效及药品不良反应。结果:治疗组总有效率达95.65%(88/92),对照组为69.57%(64/92),2组比较,差异有统计学意义(χ2=8.12,P=0.016)。药品不良反应方面,治疗组有9例发生不良反应,对照组为10例,2组比较,差异无统计学意义(P>0.05)。结论:静脉应用胺碘酮治疗骨伤科围术期快速性心律失常安全、有效。

OBJECTIVE：To evaluate the efficacy and safety of amiodarone for tachyarrhythmia in orthopedic patients during perioperative period.METHODS： 184 orthopedic patients with tachyarrhythmia during perioperative period were randomly divided into two groups of 92 each： the treatment group was intravenously administered with loading dose of amiodarone then maintained by drip infusion,and the control group was intravenously administered with metoprolol tartrate injection once daily.The efficacy for arrhythmia and the adverse drug reactions in the two groups were followed.RESULTS： The total response rate in the treatment group vs.the control group was 95.65%（88/92） vs.69.57%（64/92）,showing significant differences between the two groups（χ2=8.12,P=0.016）.9 cases in the treatment group vs.10 in the control group presented with adverse drug reactions,showing no significant differences between the two groups（P0.05）.CONCLUSION： Intravenous administration of amiodarone was proved to be safe and effective for tachyarrhythmia in orthopedic patients during perioperative period.