摘要
目的:探讨在采用综合治疗并给予布地奈德+特布他林雾化吸入的基础上加用异丙托溴铵雾化吸入对儿童中重度支气管哮喘急性发作的临床疗效及对肺功能的影响。方法:将400例中重度支气管哮喘急性发作患儿以随机数字表法分为治疗组和对照组各200例,2组均给予临床通用的综合治疗,对照组再给予布地奈德+特布他林雾化吸入治疗,治疗组则给予异丙托溴铵联合布地奈德+特布他林雾化吸入,比较2组患者临床症状和肺功能改善情况。结果:治疗组完全缓解128例(占64%),显效58例(占29%),好转10例(占5%),无效4例(2%),总显效率为93%(186/200),总有效率为98%(196/200);对照组完全缓解104例(占52%),显效52例(占26%),好转26例(占13%),无效18例(占9%),总显效率为78%(156/200),总有效率为91%(182/200);治疗组总显效率、总有效率均显著高于对照组(P<0.01)。治疗前2组患者第1秒最大呼气量(FEV1)、第1秒最大呼气量占预计值百分比(FEV1%)比较,差异无统计学意义,治疗后均显著升高(P均<0.001),但治疗组较对照组升高更明显(P<0.001)。结论:异丙托溴铵联合布地奈德+特布他林雾化吸入治疗儿童中重度支气管哮喘急性发作,较单纯布地奈德+特布他林雾化吸入更加高效、快捷。
OBJECTIVE：To evaluate the curative efficacy of ipratropine combined with budesonide and terbutaline via atomization inhalation plus comprehensive therapy for moderate or severe acute episode of bronchial asthma in children and especially their effect on patients＇ lung function.METHODS： 400 children with moderate or severe acute episode of bronchial asthma were randomly divided into treatment group and control group of 200 each.Both groups received comprehensive treatment as suggested in the guidelines.Moreover,the control group was treated with budesonide and terbutaline by aerosol inhalation,and the treatment group was treated with ipratropine combined with budesonide and terbutaline by aerosol inhalation.The two groups were compared with regard to improvement in clinical symptoms and lung function.RESULTS： In the treatment group,the overall excellently effective rate was 93%（186/200） and total effective rate was 98%（196/200）,with complete remission in 128 patients（64%）,excellent efficacy in 58（29%）,improvement in 10（5%） and treatment failure in 4（2%）,as compared with the overall excellently effective rate of 78%（156/200）,total effective rate of 91%（182/200）,complete remission in 104（52%）,excellent efficacy in 52（26%）,improvement in 26（13%） and treatment failure in 18（2%） of the control group,with treatment group showing significantly higher total excellently effective rate and total effective rate than in the control group（P0.01）.Before treatment,there were no significant differences between the two groups in FEV1 and FEV1%（P0.001）;however,both group showed significant increase in FEV1 and FEV1% after treatment（P0.001）,much as in the treatment group（P0.001）.CONCLUSION： The addition of ipratropine combined with budesonide and terbutaline via atomization inhalation to comprehensive therapy resulted in more effective and rapid efficacy than did budesonide plus terbutaline in the treatment of moderate or severe acute episode of bronchial asthma in children.
出处
《中国医院用药评价与分析》
2012年第12期1113-1115,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
