二丁二仙汤治疗慢性尿路感染临床疗效评价及免疫调节作用研究

Clinical Effects of “Erding Erxian Decoction” in Treating Chronic Urinary Tract Infection and Its Immune Regulation Function

目的:探讨二丁二仙汤治疗慢性尿路感染的临床疗效及其可能存在的免疫调节作用。方法:将99例肾精亏虚、余邪不清型慢性尿路感染女性患者随机分为中药组、抗生素组和宁泌泰组,每组33例。中药组给予二丁二仙汤治疗,抗生素组采用单剂量抗生素长程抑菌治疗,宁泌泰组予以宁泌泰胶囊口服,疗程均为12周。观察三组患者的临床疗效、主要临床症状及治疗前后血免疫球蛋白IgG、IgA、IgM水平的变化情况。结果:①治疗后,中药组、抗生素组和宁泌泰组的总有效率分别为93.55%、68.96%和58.62%,中药组的疗效优于抗生素组及宁泌泰组(P<0.05)。②治疗后,中药组患者的临床症状总积分、虚证症状积分较治疗前显著下降(P<0.05),且中药组患者的总积分、虚证症状积分较抗生素组及宁泌泰组亦显著降低(P<0.05)。③治疗后,中药组和抗生素组患者的IgG水平均显著升高(P<0.05),且中药组IgG水平较抗生素组及宁泌泰组亦显著升高(P<0.05)。结论:二丁二仙汤治疗肾精亏虚、余邪不清型中老年女性慢性尿路感染疗效较好,且具有一定的免疫调节作用。

Objective： To explore the clinical effects of “ Erding Erxian Decoction”in treating chronic urinary tract infection and its immune regulation function. Methods： Ninety-nine female patients with chronic urinary tract infection of kidney-essence deficiency and unclearness of residual evil type were randomly divided into traditional Chinese medicine group, antibiotic group and Ningmitai group, with thirty-three cases in each group. The traditional Chinese medicine group was treated by “Erding Erxian Decoction”, the antibiotic group was treated by single-dose antibiotic for long-term bacteriostasis, and the Ningmitai group was treated by “Ningmitai Capsule”, with a course of 12 weeks. The clinical effects, main clinical symptoms and the levels of IgG, IgA and IgM were observed. Results ： ①After treatment, the total effective rates of traditional Chinese medicine group, antibiotic group and Ningmitai group were 93.55% , 68.96% and 58.62% respectively, and the clinical effects of traditional Chinese medicine group was better than those of antibiotic group and Ningmitai group （ P 〈0.05 ）. ②After treatment, the total clinical symptom scores and the deficiency-syndrome symptom scores in traditional Chinese medicine group were markedly decreased （P〈0.05）, and the total scores and deficiency-syndrome symptom scores of traditional Chinese medicine group were lower than those of antibiotic group and Ningmitai group （P 〈0.05 ）.③After treatment, the level of IgG in traditional Chinese medicine group and antibiotic group was obviously increased （ P 〈 0.05 ） , and the level of IgG of traditional Chinese medicine group was higher than that of antibiotic group and Ningmitai group （ P 〈 0.05 ）. Conclusion ： “Erding Erxian Decoction” has good effects on female patients with chronic urinary tract infection of kidney-essence deficiency and unelearness of residual evil type, and it also has some immune regulation function.