血尿宁治疗慢性肾小球肾炎血尿的临床观察

Clinical observation of “Xue Niao Ning” in treating chronic glomerular hematuria

目的观察血尿宁治疗慢性肾小球肾炎血尿的临床疗效及对免疫、血液流变学指标的影响。方法将67例慢性肾小球肾炎血尿患者随机分为治疗组(34例)和对照组(33例),两组均予西医常规治疗;治疗组同时加服血尿宁,对照组加服肾炎康复片;两组疗程均为6个月,观察临床疗效及中医证候积分、尿常规、尿沉渣红细胞计数、免疫学、血液流变学的变化情况。结果①治疗组、对照组总有效率分别为91.18%、45.45%;组间临床疗效比较,差异有统计学意义(P<0.01)。②治疗前后组内比较,治疗组腰脊酸痛、疲倦乏力、尿色异常、面色晦暗积分差异有统计学意义(P<0.05),对照组腰脊酸痛、面色晦暗积分差异有统计学意义(P<0.05);组间治疗后比较,腰脊酸痛、疲倦乏力、尿色异常积分差异有统计学意义(P<0.05)。③两组治疗前后组内比较,尿红细胞定性、尿沉渣红细胞计数差异均有统计学意义(P<0.05);组间治疗后比较,尿红细胞定性、尿沉渣红细胞计数差异有统计学意义(P<0.05)。④治疗前后组内比较,治疗组C3、纤维蛋白原差异有统计学意义(P<0.05),对照组各指标差异均无统计学意义(P>0.05);组间治疗后比较,C3、纤维蛋白原差异有统计学意义(P<0.05)。结论血尿宁可以改善慢性肾小球肾炎血尿患者的临床症状,其作用机制可能为调节机体免疫状态、改善血液流变学。

Objective To observe the clinical effect, immune regulation and hemorheology in treating chronic glomerular henmturia with ＂ Xue Niao Ning＂. Methods Sixty-seven subjects were randomized into two groups and given conventional modality： treatment group in which 34 cases were treated with ＂Xue Niao Ning＂ and control group in which33 cases were treated with ＂Shenyan Kangfu Tablets＂, with a course of 6 months. The changes of syndrome scores and laboratory indexes of urine routine, urinary sediment RBC, immunology and haemorheology were observed. Results （1）The total effective rate was 91.18% in the treatment group aml 45.45% in the control group, with a significant difference between the two groups（ P 〈0.01 ）. （2）The scores of the lumbar pain, fatigability, abnormal urine color and dark complexion were of significant differences between before and after treatment in the treatment（ P 〈0.05） ; and in the control group, only the scores of the lumbar pain and dark cmuplexion were of significant differences between before and after treatment （ P 〈 0.05 ） ; the differenee of the syndrome scores, such as fatigability, lumbar pain and abnormal urine color were of statistical signifieances between the two groups after treatment（ P 〈 0.05 ）. （3）The laboratory indexes of urine routine and urinary sediment RBC were of significant differences in the two groups between before and alter treatmeut（P 〈 0.05 ） ; the difference of the two indicators had statistical significanees between the two groups after treatment（P 〈 0.05 ）. （4）The laboratory indexes of C3 and fibrinogen had significant diffel^nces in the treatment group between before and after treatment （ P 〈 0.05 ） , and the two indicators had no statistical significance in the control group （P 〉0.05）. The difference of the laboratory indexes of C3 and fibrinogen had statistical significances between the two groups after treatment （P 〈 0.05 ）. Conclusion ＂Xue Niao Ning＂ is effective for chronic glomerular hematuria possibly by egulating the body＇ s immune function and improving blood rheology.