耐碳青霉烯鲍曼不动杆菌感染及其耐药性研究

STUDY ON INFECTION AND DRUG RESISTANCE OF CARBAPENEM-RESISTANT Acinetobacter baumanii

目的了解耐碳青霉烯鲍曼不动杆菌感染的临床分布及耐药性,为临床合理选用抗菌药物提供依据。方法通过感染标本分离鉴定方法和药敏试验,对感染患者标本进行了鲍曼不动杆菌感染分布和耐药性检测。结果从某医院2011年度感染病人不同标本中共检出鲍曼不动杆菌796株,其中包括耐碳青霉烯鲍曼不动杆菌269株,构成比为33.8%。以呼吸道标本检出率最高,占88.8%;感染病人主要分布在重症监护室,占63.6%。耐碳青霉烯鲍曼不动杆菌对多数抗菌药物耐药率达到50%以上,只对丁胺卡那和妥布霉素及多粘菌素B保持较高的敏感性。结论该医院感染患者标本中耐碳青霉烯鲍曼不动杆菌检出率较高,该菌株普遍耐药,应当通过加强手卫生和环境消毒以及合理应用抗菌药物加以防控。

Objective To learn the clinical distribution and the drug resistance of Carbapenem - resistant Acinetobacter baumanii infection, provide the basis for reasonably selecting antibiotics. Methods The Infection specimen separation and identification method and the drug sensitivity tests were used to detect the Acinetobacter baumanii infected patient specimens ~ clinical distribution and the drug resistance detection. Results 796 strains of Acinetobacter baumanii were detected in dif- ferent infected patient specimens in 2011. Of them 269 strains of Carbapenem - resistant Acinetobacter baumanii（ 33.8% ） were isolated. Detection specimens were mostly in respiratory tract（ 88.8% ）. Infected patients were mainly distributed in ICU （63.6%）. Drug resistance of Carbapenem - resistant Acinetobacter baurnanii to most Antibiotics were over 50%. Car- bapenem - resistant Acinetobacter baumanii had a high sensitivity to amikacin and tobramycin and polymyxin B. Coulusion Carbapenem - resistant Acinetobacter baumanii had a higher detection rate in infected patient specimens in our hospital. The strains had widespread resistance. So hand hygiene and environmental sanitation should be strengthened and make sure that antimicrobial drugs are properly used to prevention and control.