摘要
目的了解血液病患者真菌感染发生率、病原菌构成及其耐药性变迁,为临床抗真菌药物的合理应用提供参考。方法通过真菌分离和鉴定及药敏试验方法,对住院血液病患者医院内获得真菌的感染标本进行了真菌学检测和药敏试验结果分析。结果从3 929份病人标本中检出病原菌共894株,其中真菌260株,占29.1%。真菌分离率由2009年22.1%上升到2011年34.3%,其中白色念珠菌和光滑假丝酵母菌分别居前2位。所分离出的真菌对5-氟胞嘧啶、制霉菌素、伏立康唑、两性霉素B等抗真菌药物均保持较高的敏感性,耐药性无明显改变,而对伊曲康唑和氟康唑耐药率有所增加。结论血液病患者真菌感染总体呈上升趋势,其耐药率逐年提高,应加强抗真菌药物应用管理。
Objective To know the fungal infection incidence,pathogen constitution and drug-resistance shift of hematologic disorders,and to provide reference for rationale use of antifungal agents.Methods Fungi isolation and identification and drug sensitivity test methods were used to analyze fungi infection specimens of hematologic disorders in hospital.Results 894 strains of pathogenic bacterial were detected from 3 929 patients specimens.Fungi were 260 strains,which accounting for 29.1%.Fungi isolation rate raised from 22.1% in 2009 to 34.3% in 2011.Among them,Candida albicans and Candida glabrata were the first.Those isolated fungal were high sensitive to 5-fluorocytosine,nystatin,voriconazole and amphotericin.However,sensitivity to itraconazole and fluconazole gradually increased.Conclusion Fungal infection rate has increased in recent years,and drug-resistance become more common.Management of antifungal drugs should be strengthened.
出处
《中国消毒学杂志》
CAS
北大核心
2013年第2期129-131,共3页
Chinese Journal of Disinfection
关键词
真菌感染
抗真菌药物
耐药性
fungal infections
antifungal drugs
drug resistance
