赛乐特对急性缺血性脑卒中伴言语障碍患者运动功能康复的影响

Effect of paroxetine for motor recovery after acute ischemic stroke with language disorder

目的观察预防性应用赛乐特对伴有言语障碍的急性缺血性脑卒中患者运动功能康复的影响。方法将80例伴有言语障碍的缺血性脑卒中患者随机分为赛乐特组和对照组各40例,2组均给予急性缺血性脑卒中常规治疗如抗血小板聚集、控制危险因素、稳定动脉粥样硬化斑块等和其他康复治疗,赛乐特组加用赛乐特20 mg晨服,每日1次。卒中起病后7d内、90d,采用简化Fugl-Meyer运动功能评分(FMMS)评价运动功能,美国国立卫生研究院卒中量表(NIHSS)、日常生活Barthel指数评价患者的神经功能损害程度和日常生活活动能力。结果卒中后90d,赛乐特组患者上、下肢FMMS评分分别为29.7±22.2、24.0±7.9,高于对照组的16.2±16.6、18.9±8.2(P<0.05);上、下肢FMMS增加分数评分分别为24.2±19.8,12.4±4.8,高于对照组的11.8±14.8、10.1±4.2(P均<0.05)。赛乐特组NIHSS评分较对照组明显降低,Barthel指数较对照组明显升高(P<0.05)。结论预防性应用赛乐特可以促进伴有言语障碍的缺血性脑卒中患者的运动功能康复,提高总体康复水平。

Objective To observe the effect of paroxetine for motor recovery after acute ischemic stroke with language disorder.Methods A total of 80 patients of acute ischemic stroke with language disorder were randomized int6 paroxetine group（40 cases） and control group（40 cases）.Conventional therapy was given to both groups.In the paroxetine group,paroxetine （20 mg） was given at the same time.The motor recovery status was assessed with Fugl Meyer motor scale（FMMS）. Meanwhile,the national institutes of health stroke scale（NIHSS） and the Barthel index of activities of daily living（ADL） were given to both groups.Results After 90 days＇ therapy,FMMS score（upper limb：29.7±22.2;Lower limb;24.0±7.9） increased significantly in Paroxetine group（n =37） than in the control group（Upper limb;16.2±16.6;Lower limb; 18.9±8.2;re =38）（P 0.05）.The total score of NIHSS of Paroxetine group were significantly lower than the control group,the Barthel index score increased significantly in Paroxetine group than in the control group（P 0.05）.Conclusion Paroxetine is effective to therapy for rehabilitation after acute ischemic stroke with language disorder.It can improve the motor recovery of patients and promote the activities of daily living.