初发和复发性脑梗死患者凝血功能指标分析

Analysis the Coagulation Fuction in Patients with First and Recurrent Cerebral Infarction

目的:分析初发和复发性脑梗死患者凝血功能指标的变化。方法:采集46例初发脑梗死患者(初发脑梗死组)和57例复发脑梗死患者(复发脑梗死组)的血液标本,应用CA7000全自动凝血仪检测血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)以及D-二聚体(D-Dimer)5项凝血指标,并与97例健康人群(健康对照组)对照分析。结果:与健康对照组比较,脑梗死患者PT、APTT、TT时间明显缩短(P<0.05或P<0.01),FIB和D-Dimer水平显著升高(P<0.05或P<0.01);复发脑梗死与初发脑梗死组PT、TT差异无统计学意义(P>0.05),但复发脑梗死患者APTT明显缩短(P<0.01),FIB和D-Dimer水平显著升高(P<0.01)。结论:脑梗死患者PT、APTT、TT、FIB、D-Dimer水平明显异常,复发脑梗死较初发脑梗死更严重。

Objective: To analysis the changes of coagulation function indexin patients with first and recurrentcerebral infarction. Method: The plasma samples of 46 patients with first cerebral infarction and 57 patients with recurrentcerebral infarction were collected in this research. We detected the level of the theprothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-Dimer and compared the results with 97 healthy people. Results: Compared with controls, cerebral infarction group was shorter in PT, APTT, TT (P<0.05 or P<0.01) and the level of FIB and D-Dimer were significantly higher (P<0.05 or P<0.01). Recurrent cerebral infarction group was shorter in APTT and much higher in the level of FIB and D-Dimer (all P<0.01) by comparing with first cerebral infarction group. Conclusion: The changes of PT, APTT, TT, FIB and D-Dimer has closely relationship with cerebral infarction, and the patients with recurrentcerebral infarction has a worse coagulation function than first cerebral infarction.