COPD急性期与缓解期血清C反应蛋白、前白蛋白、IL-8、TNF-α的变化分析

Change of C-reactive protein,pre-albumin,IL-8,TNF-α level in acute and remission stages of COPD

目的:观察慢性阻塞性肺疾病(COPD)患者在急性发作期与缓解期炎性因子血清C反应蛋白(CRP)、前白蛋白(PA)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的变化,分析其临床意义。方法:选取我院诊治的30例COPD患者为研究对象(观察组),记录该组患者急性期与缓解期血清CRP、PA、IL-8、TNF-α的水平,并与30例正常健康体检人群(对照组)进行比较。结果:观察组急性期与缓解期的TNF-α、IL-8、高敏C反应蛋白(hs-CRP)水平均显著高于对照组,而急性期与缓解期的PA水平显著低于对照组(P<0.05);观察组急性期TNF-α、IL-8、hs-CRP水平均显著高于缓解期,而PA水平显著低于缓解期(P<0.05)。结论:COPD患者急性期或缓解期TNF-α、IL-8、hs-CRP、PA与正常人群存在明显差异,与疾病严重程度相关,可作为评价临床分期及疗效的指标。

Objective： To analyze the changes of C-reactive protein（CRP）, pre-albumin（PA）, IL- 8, TNF-α in the acute and remission stages of COPD. Methods：Thirty patients with acute exacerbation of COPD （Observation group） and normal people （control group） were selected. The levels of CRP, PA , IL-8, TNF-α were detected at the acute and remission stages. And the results were compared to the con- trol group. Results： CRP, IL-8, TNF-α in patients of observation group at the acute and remission stages were higher than the control group, while PA at the acute and remission stages was lower than the controlgroup. CRP, IL-8, TNF-α in patients of observation group at the acute stage were higher than remission stage, while PA at the acute stages was lower than relieving stage. Conclusions： Plasma CRP, PA , IL-8, TNF-αlevels have obvious differences at the acute and remission stages of COPD. They are sensitive inde- xes to pulmonary infection and curative effect.