肺炎支原体感染合并支气管哮喘患儿血清总IgE及IL-5的检测及意义

Serum level of total IgE and IL-5 in children with Mycoplasma pneumoniae infection and bronchial asthma

目的:探讨肺炎支原体感染合并支气管哮喘患儿血清总IgE及IL-5的检测及意义。方法:将2011年10月～2012年2月间来我院住院治疗的符合标准的88例肺炎支原体感染的患儿作为研究对象,分成合并支气管哮喘组45例,未合并支气管哮喘组43例,采用ELISA法对所有患儿的血清总IgE及IL-5水平进行检测。结果:肺炎支原体感染患儿是否合并支气管哮喘的血清总IgE与IL-5水平差异具有统计学意义(P<0.05)。由Logistic回归分析可知,血清总IgE与IL-5升高是肺炎支原体感染合并支气管哮喘患儿发病的重要危险因素(P<0.05)。结论:血清总IgE与IL-5升高是肺炎支原体感染合并支气管发病的重要危险因素。

Objective. To study serum level of total IgE and IL-5 in children with Mycoplasma pneumoniae infection and bronchial asthma. Methods： A total of 88 cases of Mycoplasma pneumoniae in- fection admitted from October 2011 to February 2012 were chosen as study objectives. They were divided into Mycoplasma pneumoniae infection and bronchial asthma group （45 cases） and bronchial asthma group （43 cases）. Serum total IgE and IL-5 levels were tested by ELISA. Results：It showed that there was sig- nificant difference in blood serum total IgE and IL-5 levels between two groups （P〈0.05）. Logistic re- gression analysis showed that increased blood serum total IgE and IL-5 was crucial risk factor for Myco- plasma pneumoniae infection complicated with bronchial asthma （P〈0. 05）. Conclusions： Increase in blood serum total IgE and IL-5 is crucial risk factor for Mycoplasma pneumoniae infection complicated with bronchial asthma patients＂ attack.