摘要
目的了解2型糖尿病患者与正常人体内成分的差异,进一步探讨肥胖与2型糖尿病的关系。方法随机选取80例2型糖尿病患者(糖尿病组)及80例健康体检者(对照组),分别进行人体成分分析,包括体脂肪、内脏脂肪区域、骨骼肌、腰臀比及蛋白质、矿物质含量等指标,同时测定糖尿病患者的血糖、血脂、胰岛素抵抗指数、糖化血红蛋白。结果糖尿病组体脂肪[(19.68±6.78)kg]、体脂百分比[(29.87±8.04)%]、肥胖程度[(115.93±15.94)%]、内脏脂肪区域[(104.48±36.19)cm。]、体质量指数[(24.85±3.51)ks/m。]、胸围[(94.06±7.86)cm]、腰围[(85.18±9.50)cm]、腰臀比(0.90±0.05)均明显高于对照组[体脂肪:(17.31±5.55)kg、体脂百分比:(27.38±6.47)%、肥胖程度:(108.88±13.80)%、内脏脂肪区域:(85.44±44.04)cm2、体质量指数:(23.43±3.10)kg/m2、胸围:(91.11±7.52)em、腰围:(80.79±8.17)cm、腰臀比(0.86±0.05)](t值分别为2.55、2.30、3.12、2.86、2.73、2.28、3.12、4.76,P均〈0.05),而体质量控制[(-7.01±7.49)kg]、肥胖控制[(-8.53±6.66)kg]、肌肉控制[(1.52±1.43)kg]均低于对照组[体质量控制:(-4.08±6.79)蚝、肥胖控制:(-6.39±5.78)kg、肌肉控制:(2.31±2.09)kg(t值分别为-2.59、-2.17、-2.15,P均〈0.05)。糖尿病组尿酸与体质量控制、肥胖控制呈负相关(r值分别为-0.43、-0.42,P均〈0.01),与内脏脂肪区域、体脂百分比、腰臀比、体质量指数、肥胖程度、胸围、腰围、体脂肪呈正相关(r值分别为0.32、0.31、0.40、0.36、0.36、0.31、0.42、0.42,P均〈0.05),甘油三酯与体质量控制、肥胖控制呈负相关(r值分别为-0.44、-0.41,P均〈0.01),与体脂百分比、腰臀比、体质量指数、肥胖程度、胸围、腰围、体脂肪呈正相关(r值分别为0.27、0.35、0.46、0.46、0.35、0.42、0.42,P均〈0.05)。结论2型糖尿病患者的体脂肪含量及体脂肪分布与健康人有显著差异,中心性肥胖可能与糖尿病发生存在一定关系。
Objective To compare the body composition of diabetic and healthy subjects and to investigate the correlation between obesity and type 2 diabetes mellitus. Methods Body composition was analyzed in 80 type 2 diabetic patients ( diabetes group) and 80 healthy subjects ( control group) selected at random. They were measured for body fat mass, visceral fat area, sketedtal muscle mass, waist-hip ratio, the content of protein and mineral, etc. The blood glucose, blood fat, insulin resistance index (Homa-IR) and glycosylated hemoglobin(HbAlc) were also measured. Results The means of body fat mass( ( 19. 68 ±6.78) kg), percent body fat ( ( 29. 87 ± 8.04 ) % ), obesity degree ( ( 115.93 ± 15.94 ) % ), visceral fat area ( ( 104. 48 ± 36. 19) cm2 ), Body mass index (BMI) ( (24. 85 ± 3.51 ) kg/m2 ), chest circumference ( (94.06 ± 7. 86) cm), waist circumference ( ( 85.18 ± 9. 50) cm) and waist-hip ratio (0. 90 ± 0. 05 ) were significantly higher than the means of healthy subjects'weight control( ( -4. 08 ±6. 79) kg) ,body fat mass( ( 17. 31 ±5.55) kg), percent body fat ( (27. 38 ± 6.47 )% ), obesity degree ( ( 108.88 ± 13. 80 )% ), visceral fat area ( (85.44 ± 44. 04) cm2) ,BMI( (23.43 ±3.10) kg/m2) ,chest circumference( (91.11 ±7.52) cm) ,waist circumference ( (80. 79 ± 8. 17) cm) and waist-hip ratio (0. 86 ± 0.05 ) ( t = 2. 55,2. 30,3.12,2. 86,2. 73,2. 28,3.12 and 4. 76 respectively; P 〈 0. 05 ), body mass control ( ( - 7. 01 ± 7.49 ) kg), obesity control ( ( - 8. 53 ± 6. 66 ) kg) ,muscles control( ( 1.52 ± 1.43 ) kg) were lower than control group :the body mass control( ( - 4. 08 ± 6. 79) kg), obesity control ( ( - 6. 39 ± 5.78 ) kg), muscles control ( ( 2. 31 ± 2.09 ) kg). The uric acid was negatively related to weight control and obesity control ( r = - 0. 43, - 0. 42 ; P 〈 0.01 ), and were positively related to visceral fat area, percent body fat, waist-hip ratio, BMI, obesity degree, chest circumference, waist circumference and body fat mass ( r = 0. 32,0. 31,0. 40, 0. 36, 0. 36, 0. 31,0. 42,0. 42; P 〈 0.05 ) . The triglyceride was negatively related to weight control and obesity control( r = -0. 44,-0. 41 ;P 〈 0. 01 ), and were positive related to percent body fat, waist-hip ratio, BMI, obesity degree, chest circumference, waist circumference and body fat mass(r =0. 27,0. 35,0. 45,0. 46,0. 35,0. 42,0. 42;P 〈0. 05). Conclusion The body fat and fat distribution are significantly different between diabetic and healthy subjects. There may be some relationship between central obesitv and diabetes.
出处
《中国综合临床》
2013年第3期232-236,共5页
Clinical Medicine of China