脂联素基因-11377C／G多态性与缺血性脑卒中的相关性

Correlation Between -11377C/G Polymorphism in Adiponectin Gene and Ischemic Stroke

【目的】探讨脂联素基N（ADIPOQ）一11377C／G多态性与缺血性脑卒中的相关性。【方法】用聚合酶链式反应一限制性片段长度多态性方法检测302例缺血性脑卒中患者和338例健康对照者的ADIPOQ基因11377C／G位点的基因型。【结果】①病例组的GG基N型和G等位基因频率明显高于对照组（P=0．034和P=-0.010）。②GG基因型携带者发生缺血性脑卒中的危险是CC基N型携带者的2．062倍（95％Cl：1．145～3．715；P=0．016），校正各种混杂因素后发病危险度为2．165倍（95％CI：1．116～4．197；P-0．022）。③11377C／G位点与动脉粥样硬化性脑梗死的发病有关，与腔隙性脑梗死的发病无关。【结论】AD-IPOQ基因的-11377C／G位点的GG基因型和G等位基因可能增加缺血性脑卒中的发病风险，特别是动脉粥样硬化性脑梗死的发病风险，其可能是缺血性脑卒中的危险因素。

[Objective] To explore the association between the -11377 C/G polymorphism in adiponectin （ADIPOQ） gene and ischemic stroke. [Methods]Polymerase chain reaction-restriction fragment length poly- morphism（PCR-RFLP） method was used to detect the genotypes of -11377C/G site of ADIPOQ gene in 302 patients with ischemic stroke and 338 healthy controls. [Results]The frequencies of GG genotype and G allele in case group were obviously higher than those in control group（ P=0. 034 and P = 0. 010）. The GG genotype carriers had a significantly higher risk of ischemic stroke with OR 2. 062 （95~CI..1. 145-3. 715; P =0. 016） than the CC genotype carriers. After adjustment for potential risk factors, -11377 C/G polymorphism re- mained positive correlation with ischemie stroke（OR： 2. 165; 95%CI = 1. 116--4. 197; P =0. 022）. The - 11377C/G site was associated with atherosclerotic cerebral infarction, but not associated with lacunar infarc- tion. [Conclusion] The GG genotype and G allele of the -11377C/G polymorphism of ADIPOQ gene may in- crease the risk of ischemic stroke, especially atherosclerotic cerebral infarction. The ADIPOQ gene maybe is the risk factor of ischemic stroke.