卡泊三醇联合窄谱中波紫外线治疗轻中度斑块状银屑病疗效观察

Clinical Effect of Calcipotriol Combined with Narrow-Band UltravileB on Mild-to-Moderate Plaque Psoriasis

目的探讨窄谱中波紫外线(NB-UVB)联合卡泊三醇软膏治疗轻中度斑块状银屑病的临床疗效。方法选取110例斑块状银屑病患者,按随机原则分为观察组和对照组,两组各55例,观察组采用NB-UVB照射联合卡泊三醇软膏外用进行治疗,对照组单用NB-UVB照射治疗,两组均治疗12周后采用PASI积分评价疗效。结果 3个疗程结束后,观察组PASI评分显著低于对照组,两组比较差异有统计学意义(P<0.05);观察组总体疗效为90.9%,优于对照组76.4%,两组比较有显著性差异(P<0.05)。结论卡泊三醇联合窄谱中波紫外线治疗轻中度斑块状银屑病起效快、疗效好、不良反应少,可作为治疗此类型银屑病的优选方案之一。

Objective To observe the clinical effect of calcipotriol combined with narrow-band ultravileB on mild-to-moderate plaque psoriasis. Methods 110 patients with plaque psoriasis were divided randomly into treatment group（55 cases） and control group（55 cases）. Calcipotriol combined with narrow-band ultravileB were used in treatment group, while narrow-band ultravileB in control group, therapeutic effect of both groups were observed after 12 weeks by psoriasis area and severity index（PASI）. Results After 3 courses of treatment, the PASI of treatment group was significantly lower than that of control group, and the overall effect of treatment group （90.9%） was significantly superior to that of control group（76.4%） （all P 〈0.05）. Conclusion Calcipotriol combined with narrow-band ultravileB on mild-to-moderate plaque psoriasis has quicker onset, better efficacy, and lower rate of adverse reactions, which can be used as one of the preferred formula for the treatment of mild-to-moderate plaque psoriasis.