联合检测ADA、CEA、CRP、淀粉酶在鉴别结核性和恶性胸腔积液中的诊断价值

Diagnostic Value of Combined Detection of ADA and CEA,CRP and Amylase in the Differential Diagnosis of Tuberculous and Malignant Pleural Effusion

目的:探讨联合检测腺苷脱氨酶(ADA)、癌胚抗原(CEA)、C反应蛋白(CRP)和淀粉酶在鉴别结核性与恶性胸腔积液中的诊断价值。方法:选取胸腔积液患者117例,分为结核组72例和恶性组45例,每组均留取胸腔积液检测ADA、CEA、CRP和淀粉酶。结果:结核组胸腔积液ADA和CRP均高于恶性组,差异有统计学意义(P<0.001);恶性组胸腔积液CEA和淀粉酶均高于结核组,差异有统计学意义(P<0.001)。结论:联合检测腺苷脱氨酶(ADA)、癌胚抗原(CEA)、C反应蛋白(CRP)和淀粉酶对于结核性和恶性胸腔积液的鉴别诊断有更高参考价值,胸腔积液中ADA和CRP增高时支持结核性胸腔积液诊断,而CEA和淀粉酶增高则倾向于诊断恶性胸腔积液。

Objective： To investigate the combined detection of adenosine deaminase （ ADA ）, carcinoembryonic antigen （ CEA ）, C-reactive protein （ CRP ） and amylase in the diagnostic value in the differential diagnosis of tuberculous and malignant pleural effusion. Method： 117 patients with pleural effusion, 45 cases divided into 72 cases of tuberculous and malignant group, for each patient, specimens from the pleural effusion detected ADA, CEA, CRP and amylase. Result： tuberculous pleural effusion, ADA and CRP were higher than the malignant group, the difference was statistically significant （ P〈0.001 ） ; the malignant group and pleural effusion CEA and amylase were higher than the TB group, the difference was statistically significant （ P〈0.001 ） . Conclusion： The combined detection of adenosine deaminase （ ADA ） and earcinoembryonic antigen （ CEA ）, C-reactive protein （ CRP ） and amylase for the differential diagnosis of tuberculous and malignant pleural effusions have a higher reference value, and pleural effusionADA and CRP level support the diagnosis of tuberculous pleural effusion, CEA and amylase tended to the diagnosis of malignant pleural effusions.