登革病毒抑制剂的研究进展

Development of inhibitors against dengue virus

登革病毒(dengue virus)是严重危害人类身体健康和生命的主要病毒之一,目前尚无有效的治疗药物和疫苗。近年来,人们在抗登革病毒的药物研究方面已取得较大成果,本文结合目前抗登革病毒研究的最新进展,从病毒多聚酶和蛋白酶抑制剂、病毒复制相关宿主因子抑制剂、病毒进入阻断剂,以及抗病毒反义寡核苷酸和小干扰RNA等几个方面做一综述。

Dengue virus（DENV） infections constitute one of the most prevalent infectious diseases worldwide,causing millions of infections annually.No antiviral therapy or vaccine is currently available for the treatment of DENV infection.In recent years,considerable studies on inhibitors of DENV have been done.In this review,we present recent progresses for development of DENV inhibitors.The inhibitors against viral protease and polymerase,host factors involved in virus replication,virus entry,and oligonucleotide antiviral inhibitors such as antisense agents and small interfering RNA are summarized.