大豆皂苷药理活性及抗癌机制研究进展

Pharmacological studies and anti-cancer mechanisms of soyasaponins: research advances

大豆皂苷是豆科植物的主要药效成分之一,作为保健品、食品添加剂及化妆品长期应用,具有降血脂以及抗衰老的作用。近年来发现,其在抗炎、抗凝血、抗诱变、抗肿瘤和抑制肾素等方面亦有广泛的作用。目前大豆皂苷的抗肿瘤作用日益成为研究的热点,其作用机制可能与抑制唾液酸的表达、降低蛋白激酶活性、干扰细胞周期、破坏细胞膜及诱导凋亡有关。本文从化学组成、药理活性和抗癌作用机制等方面综述了近年来国内外大豆皂苷的研究进展,并对其未来的开发前景进行了展望。

Soyasaponins are the major bioactive ingredients in plants of Leguminosae,which have been used as food addictives,cosmetics and healthy products for a long time and have shown hypolipidemic and anti-aging effects.Recently,pharmacological studies found that soyasaponins have many other effects including anti-inflammation,anti-coagulation,anti-mutagenesis,anti-tumor and renin inhibition.Among these effects,anti-tumor function of soyasaponins is one of the hot research spots.Studies demonstrated that decreasing sialic acid,inhibiting activity of protein kinase,interfering cell cycle,disrupting cell membranes and inducing apoptosis are all the possible underlying mechanisms.In this review,the recent advances in the study on chemical structure,pharmacological activities and anti-tumor mechanism of soyasaponins are reviewed,and the future developmental prospects of soyasaponins are also discussed.