茵栀黄联合微生态制剂治疗早产儿胆汁淤积临床研究

Analysis the effection of applying Yinzhihang associated combined enteric bacterium in the parenteral nutrition associated cholestasis

目的分析茵栀黄灌肠联合微生态制剂治疗早产儿胃肠外营养相关性胆汁淤积的疗效。方法采用回顾、非随机、非双盲、分段对比的研究方法,治疗组为2010年1月至2012年3月在我院NICU住院且符合入选条件的患儿30例,均在出现胆汁淤积时,在常规治疗基础上加用茵栀黄口服液灌肠5ml/次,1日两次并口服四联活菌片0.5g/次,1日两次;对照组为2007年10月至2009年12月在我院NICU住院且符合入选条件的患儿30例,在出现胆汁淤积时予加强经口喂养并积极控制感染。搜集两组患儿生后2、3、4周的TBIL、DBIL、TBA、ALT、AST指标,并作对比分析。结果两组在生后2周各指标比较差异无统计学意义;生后3周治疗组上述指标较对照组均有所下降,差异有统计学意义,P均<0.05;生后4周治疗组上述指标较对照组进一步下降,差异有统计学意义,P均<0.05;治疗组2、3、4周上述各指标呈下降趋势。结论茵栀黄灌肠联合四联活菌制剂能促进肝脏微循环,减少胆汁淤积,改善肝脏功能,是治疗胃肠外营养相关性胆汁淤积症的有效方法。

Objective Analysis the effection of applying Yinzhihang associated combined enteric bacterium in the parenteral nutrition associated eholestasis. Methods This study enrolled 30 infants admitted between January 2010 and March 2012 who received Yinzhihang and combined enteric bacterium（cure group）and 30 infants admitted between October 2007 and December 2009 （control group）. Statistical analyses were performed by SPSS software. Results There were no significant differences between the two groups in the second weed. The index of TBIL,DBIL, TBA,ALT and AST of cure group were short of control group（P〈0.05）in the third week;The index of TBIL,DBIL,TBA,ALT and AST Of cure group were more less than control group（P〈0. 05）in the fourth week. Conclusion Yinzhihang and combined enteric bacteriumlcould reduce the parenteral nutrition associated cholestasis and improve the function of liver.