Sagliker综合征透析龄和骨代谢血液指标的初步研究

A preliminary study of dialysis age and bone metabolic blood index of Sagliker syndrome

目的:初步探讨Sagliker综合征(SS)的病因,为进一步深入研究找到方向。方法:选择在中日友好医院肾内科和口腔医学中心确诊的SS患者(SS组)8例,单纯继发性甲状旁腺功能亢进患者(SHPT组)26例,比较2组患者在性别、年龄、发病原因及骨代谢相关血液指标等方面的差异。结果:透析龄均值SS组为146±45个月,单纯SHPT组为125±24个月;SS组碱性磷酸酶(ALP)浓度为1184±662U/L、血清全段甲状旁腺激素(iPTH)浓度为2109±391pg/ml,单纯SHPT组ALP浓度为491±170U/L、iPTH浓度为2371±345pg/ml。SS组iPTH浓度每增加100pg/ml,ALP浓度增加118.8U/L;单纯SHPT组iPTH浓度每增加100pg/ml,ALP浓度增加24.6U/L。结论:透析龄可能也是Sagliker综合征的一个危险因素。单纯SHPT患者iPTH浓度升高时,ALP浓度上升幅度随iPTH浓度上升幅度较以前明显增加时,其发展成为Sagliker综合征的可能性加大。

Objective：To explore the etiology of Sagliker syndrome and find the direction of further study. Methods：Select 8 patients of Sagliker syndrome（SS group）and 26 patients simple secondary hyperparathyroidism（simple SHPT group）who were diagnosed by the Department of Nephrology and Dental Medical Center of China-Japan Friendship Hospital.Differences between the two groups on gender,age,the cause of SHPT,and several bone metabolic related blood parameters were compared.Results：For SS group,the average of dialysis age was 146±45 months and for simple SHPT group it was 125±24 months;for SS group,the alkaline phosphatase（ALP）concentration was 1184±662U/L,serum intact parathyroid hormone（iPTH）concentration was 2109± 391pg/ml,and they were 491±170U/L and 2371±345pg/ml for simple SHPT group.When the iPTH concentration had a increasing of 100pg/ml,for SS group,ALP concentration had an increasing of 118.8U/L,but for simple SHPT group,ALP concentration only had a increasing of 24.6U/L.Conclusion：Dialysis age might be a risk factor of Sagliker syndrome.For simple SHPT patients,when ALP had a significant increasing with the increasing of iPTH,the possibility that they became Sagliker syndrome increased.