摘要
小鼠牙齿发育是一个外胚层来源的上皮和神经嵴来源的间充质相互作用的过程。在这个相互作用过程中,成纤维细胞生长因子(FGFs)信号通路在牙齿发生位置的确定,牙齿发育的起始、细胞的增殖分化和牙齿的形态建成等方面都发挥着重要作用。该家族由23个配体(Fgf1-23)组成,通过4种特异性受体(FGFR1-4)来发挥作用。本文综述FGFs信号通路的配体和受体在小鼠牙齿发育中具体的表达模式及其作用。
Mouse tooth development is regulated by a series of interactions between the cranial neural crest- derived mesenchyme and the ectoderm-derived epithelium. Signaling molecules in the FGFs family appear to regulate the interactions including the determination of tooth forming sites, cell proliferation and differentiation and tooth morphogenesis. The FGFs signaling pathway consists of twenty-three growth factors （FGF1-23）, through four receptors （FGFR1-4） plays an important role in tooth development. The paper summarized the particular expression patterns and functions of all ligands （FGFs） and receptors （FGFRs） in mouse tooth development.
出处
《福建畜牧兽医》
2013年第1期14-18,共5页
Fujian Journal of Animal Husbandry and Veterinary medicine
