Guardix-SOL预防鼻腔鼻窦术后粘连的探讨

Probe into Guardix-SOL to prevent adhesion after nasal sinus surgery

目的观察鼻窦内窥镜术后涂布Guardix-SOL对鼻腔粘连、术腔黏膜转归及鼻腔舒适度的影响。方法鼻窦内窥镜手术患者随机分为对照组(104例)和实验组(108例),对照组术后按照常规进行换药和随访,实验组于手术结束及术后第一次换药时给予术腔涂布Guardix-SOL,观察对鼻腔粘连、黏膜恢复及鼻腔舒适度的影响。结果术后1个月对照组、实验组鼻腔粘连的发生率分别为21.2%和11.1%,术后6个月对照组、实验组鼻腔粘连的发生率分别为15.4%和6.5%,经卡方检验,组间差异有统计学意义。术后常规换药清理术腔,1个月及6个月时进行术腔黏膜情况评估,按照正常、轻度异常、中度异常及重度异常计,对照组与实验组两组间差异无统计学意义。对照组和实验组术后2d鼻腔舒适度评分分别为3.64±0.10及4.13±0.22,两组间差异无统计学意义。结论术腔涂布Guardix-SOL可降低术腔粘连的发生率,对术腔黏膜恢复情况及鼻腔舒适度无明显影响。

Objective To observe the influence of endoscopic sinus postoperative Guardix-SOL coating on nasal adhesions, surgical cavity mucosal outcome and nasal comfort.Methods Sufferers with endoscopic sinus surgery were randomly divided into the control group（n = 104）and the experimental group（n = 108）.The control group were given conventional dressing change and follow-up visit, while the experimental group were given surgical cavity Guardix-SOL coating at the end of the surgery and during the first dressing change.The influences on nasal adhesions, mucosal recovery and nasal comfort were observed. Results After one month, the occurrence rates of nasal adhesions in the control group and the experimental group were respectively 21.2% and 11. 1%.After six months ,the occurrence rates of nasal adhesions in the control group and the experimental group were respectively 15.4% and 6.5% ,and Chi-square Test showed the differences between the two groups were of statistical significance.The surgical cavity mucosal condition was assessed after one month and six months with conventional dressing change to clean surgical cavity in terms of normal, mildly abnormal, moderately abnormal and severely abnormal, and the differences between the control group and the experimental group were not of statistical significance.The nasal comfort scores of the control group and the experimental group two days after the surgery were 3.64 ± 0.10 and 4.13 ± 0.22, and the differences between the two groups were not of statistical significance.Conclusion Surgical cavity Guardix-SOL coating can reduce the incidence of surgical cavity adhesions but without clear influence on surgical cavity mucous recovery or nasal comfort.