新型2-[4-(3-吗啉基丙氧基)苯氧基]乙基异硫脲的合成

Synthesis of a Novel 2-[4-(3-Morpholino propoxy)phenoxy]ethyl-isothiourea

以对苄氧基苯酚为原料,经三步反应合成了2-[4-(3-氯丙氧基)苯氧基]乙醇(3);在3中引入吗啉基团制得2-[4-(3-吗啉丙氧基)苯氧基]乙醇(4);利用甲磺酰氯将4的羟基转化为离去基团,再引入硫脲基团成功地合成了新型含硫脲基的酚醚类衍生物——2-[4-(3-吗啉丙氧基)苯氧基]乙基异硫脲,其结构经1H NMR,13C NMR和MS表征。

2-[4-（2-bromoethoxy）phenoxy]ethanol（3） was prepared from p-benzyloxyphenol by a three-step reaction.2-[4-（2-morpholino propoxy）phenoxy]ethanol（4） was prepared by the reaction of 3 with morpholine.A novel 2-[4-（3-morpholino propoxy）phenoxy]ethyl-isothiourea was successfully synthesized from 4 by chlorosulfonylation,then introducing thiourea group.The structures were characterized by 1H NMR,13C NMR and MS.