2011年广州地区手足口病病原体特征分析

Analysis on pathogenic characters of hand-foot-mouth disease in Guangzhou,2011

目的了解广州地区手足口病病原体特征。方法采用Real-time PCR对2011年采集的临床诊断手足口病患者的粪便标本,同时检测肠道病毒、CoxA 16和EV71。结果共检测手足口病病例标本1 837份,肠道病毒阳性1 172份,阳性率63.80%。其中,男性阳性率为66.70%(715/1 072),女性为58.74%(457/765);CoxA 16型阳性412份,占35.67%,EV71型357份,占30.46%,CoxA 16和EV71混合感染11份,占0.94%,其他未分型肠道病毒386份,占32.94%。全年有两个发病高峰,分别为5—7月及9—11月。肠道病毒感染主要集中于0～5岁儿童,占阳性标本的96.84%(1 135/1 172)。结论 CoxA 16型和EV71型为2011年广州地区手足口病的主要病原,其他未分型肠道病毒感染亦常见,0～5岁儿童是感染的主要人群。

Objective To learn the pathogenic characters of hand--foot--mouth disease（HFMD） in Guangzhou, 2011. Methods Stool samples from patients diagnosed as HFMD were collected to detect pan--enterovirus, Cox A16 and EV 71 by using Real--time PCR. Results A total 1 837 samples were collected, 1172（63.80%） pan--enterovirus positive samples were detected during 2011. Among them, 412（35.67%） wereCoxA16, 357（30.46%） were EV71,11（0.94%） wereCoxA16 and EV71 co--infection, and 386（32.94%） were the other enterovirus. The positive rate of male was 66. 70% （715/1072）, the positive rate of female was 58. 74% （457/765）. Enterovirus infection peaked in May to July and September to November. A peak age distribution of enterovirus infection was 0 to 5 years old （96.84%）. Conclusion CoxA 16 and EVT1 was the main pathogen of HFMD in Guangzhou in 2011, CoxA 16 was the most important pathogen, and the other enterovirus infection was also very common. The positive rate of enterovirus infection of male was higher than the female. The peak season distribution was in May to July and September to November and a peak age distribution of enterovirus infection was 0 to 5 years old.