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2,6-二氯-4-三氟甲基烟腈合成的改进 被引量：3

Improvement of Synthesis of 2,6-dichloro-4-(trifluoromethyl) Nicotinonitrile
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摘要 介绍了标题化合物的合成路线的改进。以氰乙酰胺和三氟乙酰乙酸乙酯为原料,经过环合、氯代两步反应得到目标产物,并经MS和1HNMR进行了结构表征。本合成路线反应条件温和,操作方便,收率较高,适合工业化生产。反应总收率82%。 An important intermediate of pesticides and medicine drugs, was realized and manufactured from malononitrile via two steps, including cyclizationand chlorination.This program is suitable for industrial production. The total product yield was 82 %. And its structure was verified by MS and 1 HNMR.
作者 董磊 赵春深 宋吾燕
机构地区 贵州大学化学与化工学院 贵州省发酵工程与生物制药重点实验室
出处 《广东化工》 CAS 2013年第4期18-18,共1页 Guangdong Chemical Industry
关键词 2 6-二氯-4-三氟甲基烟腈 氰乙酰胺 三氟乙酰乙酸乙酯 改进 2,6-diehloro-4-（trifluoromethyl）nicotinonitrile： cyanoacetamide ethyl trifluoroa-cetoacetate improvement
分类号 TQ [化学工程]
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参考文献5

二级参考文献20

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共引文献25

同被引文献27

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广东化工
2013年 第4期

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