缺血性脑卒中患者幽门螺杆菌感染与两种血清标志物的关系

Study on relationship between helicobacter pylori infection and two serum indicator in patients with acute ischemic stroke

目的探讨缺血性脑卒中患者幽门螺杆菌(Hp)感染与血清胱氨酸蛋白酶抑制剂C(Cyc)、血脂水平变化的相关性。方法选择2011年6～12月于本院收治的缺血性脑卒中患者48例为研究对象,另选择40例健康体检者为对照组。采用酶联免疫吸附法(ELISA)和免疫比浊法检测Hp-IgG表达情况和Cyc表达水平,并检测血脂,分析Hp感染与血清Cyc、血脂表达变化之间的关系。结果缺血性脑卒中组患者Hp-IgG阳性率(77.08%)、血清总胆固醇(TC)(5.36±0.68)mmol/L、三酰甘油(TG)(1.95±0.49)mmol/L、低密度脂蛋白胆固醇(LDL-C)(3.16±0.68)mmol/L及Cyc(1.37±0.37)mg/L的表达水平均明显高于对照组[32.50%,(4.12±0.45)mmol/L,(1.15±0.39)mmol/L,(2.21±0.64)mmol/L,(0.85±0.16)mg/L](P<0.05),而缺血性脑卒中组患者高密度脂蛋白胆固醇(HDL-C)(1.02±0.29)mmol/L表达水平明显低于对照组(1.28±0.26)mmol/L(P<0.05)。Hp感染阳性缺血性脑卒中患者的血清TC(5.79±0.94)mmol/L、TG(2.09±0.62)mmol/L、LDL-C(3.46±0.72)mmol/L及Cyc(1.67±0.56)mg/L表达水平均明显高于Hp感染阴性患者[(4.85±0.69)mmol/L,(1.53±0.34)mmol/L,(2.84±0.81)mmol/L,(1.09±0.24)mg/L](P<0.05),而HDL-C(0.88±0.19)mmol/L表达水平显著低于Hp感染阴性患者(1.12±0.28)mmol/L(P<0.05)。结论 Hp感染与缺血性脑卒中发生有相关性,可能通过对血清Cyc表达水平及血脂代谢的影响而促进缺血性脑卒中的发生和演进。

Objective To explore the relationship between helicobacter pylori（Hp） infection and blood-lipoids,systatin C（Cyc） in patients with acute ischemic stroke.Methods 48 patients with acute ischemic stroke in our hospital from June to December 2012 were selected as stroke group and 40 health people as control group.Serum specific antibodies to Hp（Hp-IgG） and serum Cyc were measured in two groups by ELISA,and the blood lipids were tested.The relationship of Hp and the expression of serum Cyc and blood lipids were analyzed.Results The positive rate of Hp-IgG（77.08%） and the expression of serum TC[（5.36±0.68）mmol/L],TG[（1.95±0.49）mmol/L],LDL-C[（3.16±0.68）mmol/L] and Cyc[（1.37±0.37）mg/L] in stroke group were higher than those in control group,which were 32.50%,（4.12±0.45）mmol/L（1.15±0.39）mmol/L,（2.21±0.64）mmol/L,（0.85±0.16）mg/L（P〈0.05）.The expression of serum HDL-C[（1.02±0.29）mmol/L] in stroke group was lower than that in control group[（1.28±0.26）mmol/L]（P〈0.05）.Those who were Hp-IgG positive had significant higher levels of TC[（5.79±0.94）mmol/L],TG[（2.09±0.62）mmol/L],LDL-C[（3.46±0.72）mmol/L] and Cyc[（1.67±0.56）mg/L] than those who were Hp-IgG negative,which were（4.85±0.69）mmol/L,（1.53±0.34）mmol/L,（2.84±0.81）mmol/L,（1.09±0.24）mg/L（P〈0.05）.Those who were Hp-IgG positive had significant lower level of HDL-C[（0.88±0.19）mmol/L] than that who were Hp-IgG negative[（1.12±0.28））mmol/L]（P〈0.05）.Conclusion There is significant correlation between Hp infection and acute ischemic stroke.Hp infection may be involved in the pathogenesis of acute ischemic stroke by increasing the expression of blood lipids and Cyc.