渤海新区2687例成人糖化血红蛋白水平分析

Analysis of blood glycated hemoglobin level of 2 687 adults in Bohai New area

目的了解渤海新区糖化血红蛋白(HbA1c)水平及该地区正常参考范围。方法使用美国BIO-RAD D-10全自动糖化血红蛋白分析仪,应用高效液相色谱法(HPLC)检测2 687例健康成人体检者的HbA1c,并比较不同性别和不同年龄组间HbA1c水平差异。结果渤海新区健康成人HbA1c95%可信区间参考范围为4.29%～6.09%,男女性别间差异有统计学意义(P<0.05),>39～49岁组高于>29～39岁组(P<0.05),>49～82岁组明显高于>39～49岁组(P<0.05)。结论渤海新区HbA1c参考范围与其他地区合适水平存在差异,HbA1c水平与性别、年龄有关,可为该地区糖尿病防治工作提供依据。

Objective To investigate the present status of the blood glycated hemoglobin（ HbAlc） level and reference range in the residents of Bohai New area. Methods The fasting HbAlc levels of 2 687 adults were deter- mined and analyzed by the high performance liquid chromantography （HPLC） with the BIO-RAD D-10 fully automatic biochemistry analyzer. Then the blood HhAlc levels in different sex and age groups were compared. Results The reference range（95%confidence interval）of HbAlc in adults in Bohai New area was 4.29%- 6.09 %, There were significant differences between male and female groups （P〈0.05）, The hemoglobin level of of 〉 39- 49 age group was higher than of 〉29--39 age group（{〈0.05）, The hemoglobin level of 〉49--82 age group was obviously higher than of 〉39--49 age group（P〈0.05）. Conclusion The reference range of HbAlc in adults in Bohai New ar- ea is different from other areas,and it is related to sex and age,which provides the basis for the prevention and treat- ment of diabetes.